J
J. Chen
Researcher at Sun Yat-sen University
Publications - 24
Citations - 870
J. Chen is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Field electron emission & Scanning electron microscope. The author has an hindex of 8, co-authored 24 publications receiving 544 citations. Previous affiliations of J. Chen include Guangzhou Medical University & Chinese Ministry of Education.
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Journal ArticleDOI
XPS studies on surface reduction of tungsten oxide nanowire film by Ar+ bombardment
TL;DR: In this article, an X-ray photoelectron spectroscopy (XPS) system was used to produce uniform tungsten cone arrays during high-energy ion beam bombardment.
Journal ArticleDOI
The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι.
Yiwen Zhang,Yingshi Chen,Yuzhuang Li,Feng Huang,Baohong Luo,Yaochang Yuan,Baijin Xia,Xiancai Ma,Tao Yang,Fei Yu,Jun Liu,Bingfeng Liu,Zheng Song,J. Chen,Shu-Mei Yan,Liyang Wu,Ting Pan,Xu Zhang,Rong Li,Wenjing Huang,Xin He,Fei Xiao,Junsong Zhang,Hui Zhang +23 more
TL;DR: Wang et al. as discussed by the authors showed that SARS-CoV-2 infection leads to major histocompability complex class Ι (MHC-Ι) down-regulation both in vitro and in vivo.
Posted ContentDOI
The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Potently Downregulating MHC-I
Yiwen Zhang,Yingshi Chen,Baohong Luo,Yaochang Yuan,Feng Huang,Tao Yang,Fei Yu,Jun Liu,Bingfeng Liu,Zheng Song,J. Chen,Ting Pan,Xu Zhang,Yuzhuang Li,Rong Li,Fei Xiao,Hui Zhang +16 more
TL;DR: The results demonstrate that ORF8 protein disrupts antigen presentation and reduces the recognition and the elimination of virus-infected cells by CTLs8, suggesting that the inhibition of ORf8 function could be a strategy to improve the special immune surveillance and accelerate the eradication of SARS-CoV-2 in vivo.
Journal ArticleDOI
IL-4 Inhibits the Biogenesis of an Epigenetically Suppressive PIWI-Interacting RNA To Upregulate CD1a Molecules on Monocytes/Dendritic Cells.
Xue Zhang,Xin He,Chao Liu,Jun Liu,Qifei Hu,Ting Pan,Xiaobing Duan,Bingfeng Liu,Yiwen Zhang,J. Chen,Xingru Ma,Xu Zhang,Haihua Luo,Hui Zhang +13 more
TL;DR: It is demonstrated that a piRNA acted as the signal molecule for a cytokine to regulate the expression of an important membrane protein for lipid Ag presentation and the transcription of CD1A was significantly inhibited.
Journal ArticleDOI
RNA helicase MOV10 functions as a co-factor of HIV-1 Rev to facilitate Rev/RRE-dependent nuclear export of viral mRNAs.
Feng Huang,Junsong Zhang,Yijun Zhang,Guannan Geng,Juanran Liang,Yingniang Li,J. Chen,Chao Liu,Hui Zhang +8 more
TL;DR: This report found that MOV10 potently enhances the nuclear export of viral mRNAs and subsequently increases the expression of Gag protein and other late products through affecting the Rev/RRE axis and demonstrates the complicated effects of MOV10 on HIV-1 life cycle.