J
J. Christopher Culberson
Researcher at United States Military Academy
Publications - 18
Citations - 3111
J. Christopher Culberson is an academic researcher from United States Military Academy. The author has contributed to research in topics: Farnesyl Protein Transferase & Farnesyltransferase. The author has an hindex of 10, co-authored 18 publications receiving 2420 citations. Previous affiliations of J. Christopher Culberson include Merck & Co. & Duke University.
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Journal ArticleDOI
Random forest: a classification and regression tool for compound classification and QSAR modeling.
Vladimir Svetnik,Andy Liaw,Christopher Tong,J. Christopher Culberson,Robert P. Sheridan,Bradley P. Feuston +5 more
TL;DR: It is the combination of relatively high prediction accuracy and its collection of desired features that makes Random Forest uniquely suited for modeling in cheminformatics.
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3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.
Ian M. Bell,Steven N. Gallicchio,Marc Abrams,Lorena S. Beese,Douglas C. Beshore,Hema Bhimnathwala,Michael J. Bogusky,Carolyn A. Buser,J. Christopher Culberson,Joseph P. Davide,Michelle Ellis-Hutchings,Christine Fernandes,Jackson B. Gibbs,Samuel L. Graham,Kelly Hamilton,George D. Hartman,David C. Heimbrook,Carl F. Homnick,Hans E. Huber,Joel R. Huff,Kelem Kassahun,Kenneth S. Koblan,Nancy E. Kohl,Robert B. Lobell,Joseph J. Lynch,Ronald G. Robinson,A. David Rodrigues,Jeffrey S. Taylor,Eileen S. Walsh,Theresa M. Williams,C. Blair Zartman +30 more
TL;DR: Optimization of this 3-aminopyrrolidinone series of compounds led to significant increases in potency, providing 83 and 85, the most potent inhibitors of FTase in cells described to date.
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Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase
Christopher J. Dinsmore,Theresa M. Williams,Timothy J. O'Neill,Dongming Liu,Rands E,J. Christopher Culberson,Robert B. Lobell,Kenneth S. Koblan,Nancy E. Kohl,Jackson B. Gibbs,Oliff Allen I,Samuel L. Graham,George D. Hartman +12 more
TL;DR: The design and syntheses of non-thiol inhibitors of farnesyl-protein transferase are described, which led to highly potent imidazole-containing diarylethers and diarylsulfones and Polar diaryl linkers dramatically improved potency and gave highly cell active compounds.
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Conformational Restriction of Flexible Ligands Guided by the Transferred NOE Experiment: Potent Macrocyclic Inhibitors of Farnesyltransferase
Christopher J. Dinsmore,Michael J. Bogusky,J. Christopher Culberson,Jeffrey M. Bergman,Carl F. Homnick,C. Blair Zartman,Scott D. Mosser,Michael D. Schaber,Ronald G. Robinson,Kenneth S. Koblan,Hans E. Huber,Samuel L. Graham,George D. Hartman,and Joel R. Huff,Theresa M. Williams +14 more
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Comparison of knowledge-based and distance geometry approaches for generation of molecular conformations.
Bradley P. Feuston,Michael D. Miller,J. Christopher Culberson,and Robert B. Nachbar,Simon K. Kearsley +4 more
TL;DR: The knowledge-based approach, internally named et for enumerate torsions, differs from previous database-mining approaches by employing a library of much larger substructures while treating open chains, rings, and combinations of chains and rings in the same manner.