J
J M Jessup
Researcher at University of Texas MD Anderson Cancer Center
Publications - 1
Citations - 2708
J M Jessup is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Gene & Mutant. The author has an hindex of 1, co-authored 1 publications receiving 2666 citations.
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Mutations in the p53 gene occur in diverse human tumour types
Janice M. Nigro,Suzanne J. Baker,Antonette C. Preisinger,J M Jessup,R. Hostetter,Karen R. Cleary,S H Bigner,Nancy E. Davidson,Stephen B. Baylin,Peter Devilee +9 more
TL;DR: It is suggested that most tumours with allelic deletions of chromosome 17p contain p53 point mutations resulting in amino-acid substitutions, and p53 gene mutations are clustered in four 'hot-spots' which exactly coincide with the four most highly conserved regions of the gene.