J
J.M. Luque
Researcher at Hoffmann-La Roche
Publications - 10
Citations - 733
J.M. Luque is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Receptor & Monoamine neurotransmitter. The author has an hindex of 9, co-authored 10 publications receiving 692 citations.
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Journal ArticleDOI
Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography.
Josep Saura,J.M. Luque,Cesura Andrea,M. Da Prada,V. Chan-Palay,Gerda Huber,J. Löffler,J. G. Richards +7 more
TL;DR: It is concluded that enzyme radioautography with [3H]lazabemide is a reliable high resolution assay for plaque-associated astroglioses in Alzheimer's disease and might, indirectly, be a potential source of cytotoxic free radicals.
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Cellular expression of mRNAs encoding monoamine oxidases A and B in the rat central nervous system
TL;DR: In situ hybridization with 35S‐labelled oligonucleotide probes reveals further the potential of various cell populations to synthesize the isoenzymes, and homologous and heterologous patterns of expression as well as coexpression of MAO mRNAs are described.
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Cellular expression of glycine transporter 2 messenger RNA exclusively in rat hindbrain and spinal cord.
TL;DR: The results show that Glycine transporter 2 (but not glycine transporter 1) in the brainstem, spinal cord and cerebellum is probably involved in the reuptake of glycine from synapses containing classical strychnine-sensitive glycine receptors, and suggest that glycine acts as a neurotransmitter in cerebellar Golgi neurons.
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Localization of GABAA receptor subunit mRNAs in the rat locus coeruleus
TL;DR: Findings suggest that NMDA receptors in the LC are composed of unique combination(s) of subunits, e.g. 4a-2B, of as yet unknown stoichiometry, which can be exploited in the development of new anxiolytics, antidepressants, or neuroprotective agents.
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Alternatively spliced isoforms of the N-methyl-D-aspartate receptor subunit 1 are differentially distributed within the rat spinal cord.
TL;DR: It is demonstrated that subunit 1 splice variants are differentially distributed in the rat cervical cord and, since they fall into two physiologically and pharmacologically distinct groups, may reveal the distribution of antagonist- and agonist-preferring N-methyl-D-aspartate receptor subclasses.