J
J P Spiers
Researcher at Trinity College, Dublin
Publications - 25
Citations - 843
J P Spiers is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Protein phosphatase 2 & Endothelin receptor. The author has an hindex of 12, co-authored 25 publications receiving 791 citations. Previous affiliations of J P Spiers include Karolinska Institutet & Queen's University Belfast.
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Journal ArticleDOI
St John's Wort increases expression of P-glycoprotein: Implications for drug interactions
Martina Hennessy,Dermot Kelleher,J P Spiers,Michael J. Barry,Pierce V. Kavanagh,David Back,Fiona Mulcahy,John Feely +7 more
TL;DR: SJW increased expression and enhanced the drug efflux function of the multi drug transporter P-glycoprotein in PBMCs of healthy volunteers and may represent a second mechanism for the drug-herb interactions seen in clinical practice and account for the discrepancies between in vitro and in vivo data.
Journal ArticleDOI
A primer on the mechanics of P-glycoprotein the multidrug transporter
Martina Hennessy,J P Spiers +1 more
TL;DR: P-glycoprotein the multidrug transporter is a well-characterised member of the super-family of ATP-binding cassette (ABC) transporters, and mediates the clearance of xenotoxins against steep concentration gradients at the expense of ATP hydrolysis.
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Matrix metalloproteinase-9 polymorphism contributes to blood pressure and arterial stiffness in essential hypertension.
TL;DR: The first study to show the effect of MMP-9 polymorphism on BP and aortic stiffness in a hypertensive population is shown, suggesting that hypertensive patients carrying the T allele may be at increased risk of cardiovascular events.
Journal ArticleDOI
Alterations in vascular matrix metalloproteinase due to ageing and chronic hypertension: effects of endothelin receptor blockade.
J P Spiers,Elizabeth Kelso,Wei F Siah,Gillian Edge,Guojie Song,Barbara McDermott,Martina Hennessy +6 more
TL;DR: Ageing and the development/progression of hypertension are associated with increased MMP-2 activity in the aorta, which is consistent with ongoing remodelling of the vasculature, however, the underlying mechanisms regulating M MP-2 abundance in ageing and hypertension appear to be divergent, as MT-1 MMP expression is differentially altered.
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Activation of immune and inflammatory systems in chronic heart failure: novel therapeutic approaches
TL;DR: There is an increasing evidence to suggest greater value from non‐specific anti‐inflammatory approaches, including: pentoxifylline, intravenous immunoglobulin, immune modulation therapy, growth hormones, physical training and nutrition regulation.