D
Dermot Kelleher
Researcher at University of British Columbia
Publications - 337
Citations - 17664
Dermot Kelleher is an academic researcher from University of British Columbia. The author has contributed to research in topics: T cell & Protein kinase C. The author has an hindex of 65, co-authored 335 publications receiving 16594 citations. Previous affiliations of Dermot Kelleher include Oklahoma State University Center for Health Sciences & Novartis.
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Multiple common variants for celiac disease influencing immune gene expression
Patrick Dubois,Gosia Trynka,Lude Franke,Lude Franke,Karen A. Hunt,Jihane Romanos,Alessandra Curtotti,Alexandra Zhernakova,Graham A. Heap,Róza Ádány,Arpo Aromaa,Maria Teresa Bardella,Leonard H. van den Berg,Nicholas A. Bockett,Emilio G. de la Concha,Bárbara Dema,Rudolf S N Fehrmann,Miguel Fernández-Arquero,Szilvia Fiatal,Szilvia Fiatal,Elvira Grandone,Peter M. Green,Harry J.M. Groen,Rhian Gwilliam,Roderick H. J. Houwen,Sarah E. Hunt,Katri Kaukinen,Dermot Kelleher,Ilma Rita Korponay-Szabó,Kalle Kurppa,Padraic MacMathuna,Markku Mäki,Maria Cristina Mazzilli,Owen T. McCann,M. Luisa Mearin,Charles A. Mein,Muddassar M. Mirza,Vanisha Mistry,Barbara Mora,Katherine I. Morley,Chris J. J. Mulder,Joseph A. Murray,Concepción Núñez,Elvira Oosterom,Roel A. Ophoff,Roel A. Ophoff,Isabel Polanco,Leena Peltonen,Leena Peltonen,Mathieu Platteel,Anna Rybak,Veikko Salomaa,Joachim J. Schweizer,Maria Pia Sperandeo,Greetje J. Tack,Graham Turner,Jan H. Veldink,Wieke H. M. Verbeek,Rinse K. Weersma,Victorien M. Wolters,Elena Urcelay,Bożena Cukrowska,Luigi Greco,Susan L. Neuhausen,Ross McManus,Donatella Barisani,Panos Deloukas,Jeffrey C. Barrett,Päivi Saavalainen,Cisca Wijmenga,David A. van Heel +70 more
TL;DR: This article performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects, and genotyped 113 selected SNPs with P(GWAS) < 10(-4) and 18 SNPs from 14 known loci in a further 4,918 cases and 5,684 controls.
Multiple common variants for celiac disease influencing immune gene expression
Patrick Dubois,Gosia Trynka,Lude Franke,Lude Franke,Karen A. Hunt,Jihane Romanos,Alessandra Curtotti,Alexandra Zhernakova,Graham A. Heap,Róza Ádány,Arpo Aromaa,Maria Teresa Bardella,Leonard H. van den Berg,Nicholas A. Bockett,Emilio G. de la Concha,Bárbara Dema,Rudolf S N Fehrmann,Miguel Fernández-Arquero,Szilvia Fiatal,Szilvia Fiatal,Elvira Grandone,Peter M. Green,Harry J.M. Groen,Rhian Gwilliam,Roderick H. J. Houwen,Sarah E. Hunt,Katri Kaukinen,Dermot Kelleher,Ilma Rita Korponay-Szabó,Kalle Kurppa,Padraic MacMathuna,Markku Mäki,Maria Cristina Mazzilli,Owen T. McCann,M. Luisa Mearin,Charles A. Mein,Muddassar M. Mirza,Vanisha Mistry,Barbara Mora,Katherine I. Morley,Chris J. J. Mulder,Joseph A. Murray,Concepción Núñez,Elvira Oosterom,Roel A. Ophoff,Roel A. Ophoff,Isabel Polanco,Leena Peltonen,Leena Peltonen,Mathieu Platteel,Anna Rybak,Veikko Salomaa,Joachim J. Schweizer,Maria Pia Sperandeo,Greetje J. Tack,Graham Turner,Jan H. Veldink,Wieke H. M. Verbeek,Rinse K. Weersma,Victorien M. Wolters,Elena Urcelay,Bożena Cukrowska,Luigi Greco,Susan L. Neuhausen,Ross McManus,Donatella Barisani,Panos Deloukas,Jeffrey C. Barrett,Päivi Saavalainen,Cisca Wijmenga,David A. van Heel +70 more
TL;DR: Variants from 13 new regions reached genome-wide significance and most contain genes with immune functions, with ETS1, RUNX3, THEMIS and TNFRSF14 having key roles in thymic T-cell selection.
Journal ArticleDOI
Newly identified genetic risk variants for celiac disease related to the immune response
Karen A. Hunt,Alexandra Zhernakova,Graham Turner,Graham A. Heap,Lude Franke,Marcel Bruinenberg,Jihane Romanos,Lotte C. Dinesen,Anthony W. Ryan,Davinder Panesar,Rhian Gwilliam,Fumihiko Takeuchi,William M. McLaren,Geoffrey Holmes,Peter D. Howdle,Julian R.F. Walters,David S Sanders,Raymond J. Playford,Gosia Trynka,Chris J. J. Mulder,M. Luisa Mearin,M. Luisa Mearin,Wieke H. M. Verbeek,Valerie Trimble,Fiona M. Stevens,Colm O'Morain,Nicholas P. Kennedy,Dermot Kelleher,Daniel J. Pennington,David P. Strachan,Wendy L. McArdle,Charles A. Mein,Martin C. Wapenaar,Panos Deloukas,Ralph McGinnis,Ross McManus,Cisca Wijmenga,Cisca Wijmenga,David A. van Heel +38 more
TL;DR: This extensive genome-wide association follow-up study has identified additional celiac disease risk variants in relevant biological pathways and identified seven previously unknown risk regions.
Journal ArticleDOI
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
David A. van Heel,Lude Franke,Karen A. Hunt,Rhian Gwilliam,Alexandra Zhernakova,Michael Inouye,Martin C. Wapenaar,Martin Barnardo,Graeme Bethel,Geoffrey Holmes,C. Feighery,Derek P. Jewell,Dermot Kelleher,Parveen Kumar,Simon Travis,Julian R.F. Walters,David S Sanders,Peter D. Howdle,Jill Swift,Raymond J. Playford,William M. McLaren,M. Luisa Mearin,M. Luisa Mearin,Chris J. J. Mulder,Ross McManus,Ralph McGinnis,Lon R. Cardon,Panos Deloukas,Cisca Wijmenga +28 more
TL;DR: This paper tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls, and the most significant finding (rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block.
Journal ArticleDOI
Statistical methods for analysis of high-throughput RNA interference screens
Amanda Birmingham,Laura M. Selfors,Thorsten Forster,David Wrobel,Caleb J. Kennedy,Emma Shanks,Javier Santoyo-Lopez,Dara J. Dunican,Aideen Long,Dermot Kelleher,Queta Smith,Roderick L. Beijersbergen,Peter Ghazal,Caroline E. Shamu +13 more
TL;DR: This work examines the similarities and differences between RNAi and small-molecule screens, highlighting particular characteristics of RNAi screen data that must be addressed during analysis and provides guidance on selection of analysis techniques in the context of a sample workflow.