J. Paul Justice

TL;DR: It is demonstrated that IL-10 reduces Th2 cytokine levels and eosinophilic inflammation but augments airway hyperreactivity but could contribute to the decline in pulmonary function observed in asthma.

TL;DR: The ablation of virtually all pulmonary eosinophils in OVA-treated mice resulted in a significant decrease in mucus accumulation and abolished allergen-induced airway hyperresponsiveness, demonstrating a direct causative relationship between allergenic-mediated pulmonary pathologies and eos inophils.

TL;DR: Evidence is provided that IL-10 expression promotes the development of allergen-induced smooth muscle hyperresponsiveness and adoptive transfer of mononuclear splenocytes toIL-10-sufficient severe combined immunodeficient mice indicated that lymphocytes were an important source of the IL- 10 impacting AHR development.

TL;DR: Chitin has a unique Th1 adjuvant effect on the development of Th1 immunity against a mycobacterial antigen, which is greater in IL-10-KO mice than in WT mice and down-regulates the adjUvant effect of chitin.

TL;DR: Pulmonary expression of IL-5 alone is capable of inducing CD4(+) T cell-dependent goblet cell metaplasia, apparently mediated by IL-4 receptor alpha-subunit-ligand interactions, and represents a previously unrecognized novel pathway for augmenting allergen-induced mucus production.