S
Sergei I. Ochkur
Researcher at Mayo Clinic
Publications - 57
Citations - 3243
Sergei I. Ochkur is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Eosinophil & Eosinophil peroxidase. The author has an hindex of 25, co-authored 50 publications receiving 2932 citations.
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Journal ArticleDOI
Defining a link with asthma in mice congenitally deficient in eosinophils.
James J. Lee,Dawn Dimina,Mi Mi P. Macias,Sergei I. Ochkur,Michael P. McGarry,K.R. O'Neill,Cheryl A. Protheroe,R.S. Pero,Thanh H Nguyen,Stephania A. Cormier,Stephania A. Cormier,Elizabeth Lenkiewicz,Dana Colbert,Lisa Rinaldi,Steven J. Ackerman,Charles G. Irvin,Nancy A. Lee +16 more
TL;DR: The development of an eosinophil-less mouse now permits an unambiguous assessment of a number of human diseases that have been linked to this granulocyte, including allergic diseases, parasite infections, and tumorigenesis.
Journal ArticleDOI
Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells
Elizabeth A. Jacobsen,Sergei I. Ochkur,R.S. Pero,Anna G. Taranova,Cheryl A. Protheroe,Dana Colbert,Nancy A. Lee,James J. Lee +7 more
TL;DR: It is shown that eosinophils elicit the expression of the Th2 chemokines thymus- and activation-regulated chemokine/CCL17 and macrophage-derived chemoksine/ CCL22 in the lung after allergen challenge, and blockade of these Chemokines inhibited the recruitment of effector T cells.
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The oesophageal string test: a novel, minimally invasive method measures mucosal inflammation in eosinophilic oesophagitis
Glenn T. Furuta,Amir F. Kagalwalla,James J. Lee,Preeth Alumkal,Brian T. Maybruck,Sophie Fillon,Sophie Fillon,Joanne C. Masterson,Joanne C. Masterson,Sergei I. Ochkur,Cheryl A. Protheroe,Wendy Moore,Wendy Moore,Wendy Moore,Zhaoxing Pan,Zhaoxing Pan,Katie Amsden,Zachary D. Robinson,Kelley E. Capocelli,Kelley E. Capocelli,Vince Mukkada,Vince Mukkada,Dan Atkins,Dan Atkins,David Fleischer,David Fleischer,Lindsay Hosford,Lindsay Hosford,Mark A. Kwatia,Shauna Schroeder,Shauna Schroeder,Caleb J. Kelly,Mark A. Lovell,Mark A. Lovell,Hector Melin-Aldana,Steven J. Ackerman +35 more
TL;DR: The presence of eosinophil-derived proteins in luminal secretions is reflective of mucosal inflammation in children with EoE, and the Enterotest diagnostic device is a novel, minimally invasive device for measuring oesophageal eos inophilic inflammation.
Journal ArticleDOI
A Novel Histologic Scoring System to Evaluate Mucosal Biopsies From Patients With Eosinophilic Esophagitis
Cheryl A. Protheroe,Samantha A. Woodruff,Giovanni De Petris,Vince Mukkada,Sergei I. Ochkur,Sailajah Janarthanan,John C. Lewis,Shabana F. Pasha,Tisha Lunsford,Lucinda A. Harris,Virender K. Sharma,Michael P. McGarry,Nancy A. Lee,Glenn T. Furuta,James J. Lee +14 more
TL;DR: A novel immunohistochemical scoring system was developed to address an unmet medical need to differentiate histologic specimens from patients with EoE relative to those with GERD and will provide a valuable strategy for the assessment of esophageal eosinophilia.
Journal ArticleDOI
Pivotal Advance: eosinophil infiltration of solid tumors is an early and persistent inflammatory host response
Stephania A. Cormier,Anna G. Taranova,Carrie E. Bedient,Thanh H Nguyen,Cheryl A. Protheroe,R.S. Pero,Dawn Dimina,Sergei I. Ochkur,K.R. O'Neill,Dana Colbert,Theresa R. Lombari,Stephanie L. Constant,Michael P. McGarry,James J. Lee,Nancy A. Lee +14 more
TL;DR: It is demonstrated that the infiltration of tumors by eosinophils is an early and persistent response that is spatial‐restricted, suggesting that eos inophils are part of an early inflammatory reaction at the site of tumorigenesis.