J Salotti

TL;DR: Use of CT scans in children to deliver cumulative doses of about 50 mGy might almost triple the risk of leukaemia and doses ofabout 60 m Gy might triple therisk of brain cancer.

TL;DR: Re-analysis of the cohort with additional clinical data showed an increased cancer risk after low-dose radiation exposure from CT scans in young patients, although there was evidence of some bias in the original risk estimates.

TL;DR: This is the first study of LCH to use an active surveillance method with additional sources of ascertainment, and its incidence is comparable with those in other national reports, although it is likely to be an underestimate as each method may have missed some cases.

TL;DR: The methods used to estimate typical organ-specific doses delivered by CT scans to children are described and an organ dose database from Monte Carlo radiation transport-based computer simulations using a series of computational human phantoms from newborn to adults for both male and female was established, which is the first detailed paediatric CT scan database for the UK.

TL;DR: By focusing on the issues which challenge the validity of risk estimates from CT exposures, EPI-CT will be able to address limitations of previous CT studies, thus providing reliable estimates of risk of solid tumours and leukaemia from children's CT exposures and scientific bases for the optimisation of paediatric CT protocols and patient protection.