M
Mark P. Little
Researcher at National Institutes of Health
Publications - 303
Citations - 14269
Mark P. Little is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cancer & Population. The author has an hindex of 51, co-authored 280 publications receiving 12431 citations. Previous affiliations of Mark P. Little include Imperial College London & Nuclear Electric.
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Journal ArticleDOI
Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study
Mark S. Pearce,J Salotti,Mark P. Little,Kieran McHugh,Choonsik Lee,Kwang Pyo Kim,Nicola Howe,Cécile M. Ronckers,Preetha Rajaraman,Alan W. Craft,Louise Parker,Amy Berrington de Gonzalez +11 more
TL;DR: Use of CT scans in children to deliver cumulative doses of about 50 mGy might almost triple the risk of leukaemia and doses ofabout 60 m Gy might triple therisk of brain cancer.
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Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database
Ioanna Tzoulaki,Mariam Molokhia,Vasa Curcin,Mark P. Little,Christopher Millett,Anthea Ng,Robert Hughes,Kamlesh Khunti,Martin R. Wilkins,Azeem Majeed,Paul Elliott +10 more
TL;DR: A relatively unfavourable risk profile of sulphonylureas compared with metformin for all outcomes examined is suggested; although this requires replication in other studies, it may have implications for prescribing within this class of drugs.
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Risks associated with low doses and low dose rates of ionizing radiation: why linearity may be (almost) the best we can do.
TL;DR: There is little epidemiologic or biologic evidence for these for cancer risks of low doses of ionizing radiation, and risks in moderate- and low-dose medically and occupationally exposed groups are generally consistent with those in the LSS.
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The Increase in Thyroid Cancer Incidence During the Last Four Decades Is Accompanied by a High Frequency of BRAF Mutations and a Sharp Increase in RAS Mutations
Chan Kwon Jung,Chan Kwon Jung,Mark P. Little,Jay H. Lubin,Alina V. Brenner,Samuel A. Wells,Alice J. Sigurdson,Yuri E. Nikiforov +7 more
TL;DR: An increasing age at diagnosis and greater detection of smaller-sized intrathyroidal PTCs are found and Sharply rising percentages of the follicular variant histology and RAS mutations after 2000 suggest new and more recent etiologic factors.
Journal ArticleDOI
Systematic Review and Meta-Analysis of Circulatory Disease from Exposure to Low-Level Ionizing Radiation and Estimates of Potential Population Mortality Risks
Mark P. Little,Tamara V. Azizova,Dimitry Bazyka,Simon Bouffler,Elisabeth Cardis,Sergey Chekin,Vadim V. Chumak,Francis A. Cucinotta,Florent de Vathaire,Per Hall,John Harrison,Guido Hildebrandt,Guido Hildebrandt,Victor K. Ivanov,Valeriy V. Kashcheev,S V Klymenko,Michaela Kreuzer,Olivier Laurent,Kotaro Ozasa,Thierry Schneider,Soile Tapio,Andrew M. Taylor,Ioanna Tzoulaki,Wendy Vandoolaeghe,Richard Wakeford,Lydia B. Zablotska,Wei Zhang,Steven E. Lipshultz +27 more
TL;DR: The review supports an association between circulatory disease mortality and low and moderate doses of ionizing radiation, and suggests that overall radiation-related mortality is about twice that currently estimated based on estimates for cancer end points alone.