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Showing papers by "J. Stuart Nelson published in 2022"

Journal Article•DOI•
High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by spatial molecular imaging.

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Shanshan He, Ruchir Bhatt, Carl O. Brown, Emily A. Brown, Derek L. Buhr, Kan Chantranuvatana, Patrick Danaher, Dwayne Dunaway, Ryan G. Garrison, Gary K. Geiss, Mark Gregory, Margaret L. Hoang, Rustem Khafizov, Emily E. Killingbeck, Dae Kim, Tae-Kyung Kim, Youngmi Kim, Andrew Klock, Mithra Korukonda, Alecksandr J. Kutchma, Zachary R. Lewis, Yang Xiang, J. Stuart Nelson, Giang T. Ong, Evan P. Perillo, Joseph C. Phan, Tien Phan-Everson, Erin Piazza, Tushar A. Rane, Zachary Reitz, M. Rhodes, Alyssa B. Rosenbloom, D. Ross, Hiromi Sato, Aster Wardhani, Corey A. Williams-Wietzikoski, Lidan Wu, Joseph M. Beechem 
06 Oct 2022-Nature Biotechnology
TL;DR: S spatial molecular imaging is described, a system that measures RNAs and proteins in intact biological samples at subcellular resolution by performing multiple cycles of nucleic acid hybridization of fluorescent molecular barcodes, and has high sensitivity and very low error rate.

52 citations

Journal Article•DOI•
From FOS fusions to somatic mutations in the MAPK pathway, heterogeneous genetic abnormalities cause distinct pathophysiology among subsets of epithelioid haemangiomas

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Wenbin Tan, J. Stuart Nelson
01 Mar 2022-British Journal of Dermatology
TL;DR: Somatic mutations in UBA1 define a distinct subset of relapsing polychondritis patients with VEXAS syndrome that is separate from the general population and is associated with severe adult-onset auto inflammation.
Abstract: 1 Beck DB, Ferrada MA, Sikora KA et al. Somatic mutations in UBA1 and severe adult-onset autoinflammatory disease. N Engl J Med 2020; 383:2628–38. 2 van der Made CI, Potjewijd J, Hoogstins A et al. Adult-onset autoinflammation caused by mutations in UBA1: a Dutch case series of patients with VEXAS. J Allergy Clin Immunol 2022; 149(1):432–9. 3 Ferrada MA, Sikora KA, Luo Y et al. Somatic mutations in UBA1 define a distinct subset of relapsing polychondritis patients with VEXAS. Arthritis Rheumatol 2021; 73:1886–95. 4 Georgin-Lavialle S, Terrier B, Guedon AF et al. Further characterization of clinical and laboratory features in VEXAS syndrome: largescale analysis of a multicentre case series of 116 French patients. Br J Dermatol 2022; 186:564–74.