Gary K. Geiss

TL;DR: NanoString nCounter as mentioned in this paper is a system for gene expression measurement with high multiplex capability and digital readout, which can detect individual mRNA transcripts without enzymatic reactions or bias.

TL;DR: The results suggest that the cellular response to influenza A virus infection in human lung cells is significantly influenced by the sequence of theNS1 gene, demonstrating the importance of the NS1 protein in regulating the host cell response triggered by virus infection.

TL;DR: DSP may be used to profile not only proteins and RNAs in biobanked samples but also immune markers in patient samples, with potential prognostic and predictive potential for clinical decision-making.

TL;DR: Comparisons of transcript levels for 21 genes across seven samples measured by the nCounter system and SYBR Green real-time PCR demonstrated similar patterns of gene expression at all transcript levels, demonstrating that the n counter system is more sensitive than microarrays and similar in sensitivity to real- time PCR.

TL;DR: The results show that the FDA-cleared and CE marked Prosigna test provides an accurate estimate of the risk of distant recurrence in hormone receptor positive breast cancer and is also capable of identifying a tumor's intrinsic subtype that is consistent with the previously published PCR-based PAM50 assay.