J
J. Walter Sowell
Researcher at University of South Carolina
Publications - 47
Citations - 638
J. Walter Sowell is an academic researcher from University of South Carolina. The author has contributed to research in topics: Bicyclic molecule & Carboxylic acid. The author has an hindex of 15, co-authored 47 publications receiving 625 citations.
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Synthesis and antiviral/antitumor evaluation of 2-amino- and 2-carboxamido-3-arylsulfonylthiophenes and related compounds as a new class of diarylsulfones
Chad E. Stephens,Takita Felder,J. Walter Sowell,Graciela Andrei,Jan Balzarini,Robert Snoeck,Erik De Clercq +6 more
TL;DR: Based on general SARs previously described for anti-HIV-1 diarylsulfone derivatives, a series of 2-amino- and 2-carboxamido-3-arylsulfonylthiophenes has been prepared and evaluated as potential antiviral and antitumor agents, and most of these compounds displayed significant cytotoxicity against human fibroblasts, the cells supporting CMV and VZV replication, and thus selectivity indices were low.
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One step synthesis of 6,7-dimethyl-2-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a][1,3]pyrimidines
TL;DR: In this article, a one-step synthesis of substituted pyrrolo[1,2-a][1,3]pyrimidines from acetyl methyl carbinol, 3-aminopropionic acid, and substituted acetonitriles is reported.
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Antiviral properties of new arylsulfone derivatives with activity against human betaherpesviruses
Lieve Naesens,Chad E. Stephens,Graciela Andrei,Arianna Loregian,Leen De Bolle,Robert Snoeck,J. Walter Sowell,Erik De Clercq +7 more
TL;DR: These arylsulfone derivatives represent new betaherpesvirus inhibitors with a novel mode of action that results in indirect inhibition of viral DNA synthesis.
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Synthesis of substituted 2‐amino‐3‐cyano‐4‐methylpyrroles
TL;DR: A facile route for the synthesis of substituted 2-amino-3-cyano-4-methylpyrroles from N-acetyl-α -amino ketones and malononitrile is reported in this paper.