Jaap Verweij

TL;DR: In a substantial proportion of patients, stable disease and even increase in tumor size may be associated with pathologic response to imatinib therapy, and available survival data indicate that the survival of these patients is similar to that of patients with conventional tumor response.

TL;DR: In this paper, a translocation involving a single gene family, consisting of EWS and related genes, has been identified in five different sarcomas, and its chimeric protein products could prove similarly amenable to inhibitors.

TL;DR: Pazopanib is well tolerated in patients with relapsed, advanced STS and demonstrates interesting activity that warrants additional study in patientswith leiomyosarcoma, synovial sarcomas, and other STS types.

TL;DR: In advanced soft tissue sarcoma patients for whom significant tumor volume reduction may be an important end point of a chemotherapy regimen, single-agent doxorubicin is still the standard chemotherapy against which more intensive or new drug treatments should be compared.

TL;DR: In this paper, the authors assessed activity and toxicity of topotecan in previously treated small-cell lung cancer (SCLC) patients with measurable SCLC, progressive after one first-line regimen.