J
Jack A. Dempsey
Researcher at Eli Lilly and Company
Publications - 26
Citations - 1326
Jack A. Dempsey is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Cancer & Cell cycle. The author has an hindex of 15, co-authored 25 publications receiving 1072 citations.
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Journal ArticleDOI
The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade.
David Schaer,Richard P. Beckmann,Jack A. Dempsey,Lysiane Huber,Amelie Forest,Nelusha Amaladas,Yanxia Li,Ying Cindy Wang,Erik R. Rasmussen,Darin Chin,Andrew Capen,Carmine Carpenito,Kirk A. Staschke,Linda A. Chung,Lacey M. Litchfield,Farhana F. Merzoug,Xueqian Gong,Philip W. Iversen,Sean Buchanan,Alfonso De Dios,Ruslan D. Novosiadly,Michael Kalos +21 more
TL;DR: Data from murine syngeneic tumor models and in vitro assays support the clinical investigation of the combination of abemaciclib with agents such as anti-PD-L1 that modulate T cell anti-tumor immunity.
Journal ArticleDOI
Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib
Xueqian Gong,Lacey M. Litchfield,Yue Webster,Li-Chun Chio,Swee Seong Wong,Trent R. Stewart,Michele Dowless,Jack A. Dempsey,Yi Zeng,Raquel Torres,Karsten Boehnke,Cecilia Mur,Carlos Marugán,Carmen Baquero,Chunping Yu,Steven M. Bray,Isabella H. Wulur,Chen Bi,Shaoyou Chu,Hui-Rong Qian,Philip W. Iversen,Farhana F. Merzoug,Xiang S. Ye,Christoph Reinhard,Alfonso De Dios,Jian Du,Charles W. Caldwell,Maria Jose Lallena,Richard P. Beckmann,Sean Buchanan +29 more
TL;DR: A subset of cancers highly sensitive to CDK4/6 inhibition is reported and characterized by various genomic aberrations known to elevate D-cyclin levels and a recurrent CCND1 3'UTR mutation associated with increased expression in endometrial cancer is described.
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LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms.
Constance King,H. Bruce Diaz,Samuel McNeely,Darlene S. Barnard,Jack A. Dempsey,Wayne Blosser,Richard P. Beckmann,David Anthony Barda,Mark S. Marshall +8 more
TL;DR: The characterization of a novel CHK1 inhibitor, LY2606368, which as a single agent causes double-stranded DNA breakage while simultaneously removing the protection of the DNA damage checkpoints is described, suggesting replication catastrophe as the mechanism of DNA damage.
Journal ArticleDOI
Mitotic requirement for aurora A kinase is bypassed in the absence of aurora B kinase
Hui Yang,Teresa F. Burke,Jack A. Dempsey,Bruce Diaz,Elizabeth Collins,John E. Toth,Richard P. Beckmann,Xiang Ye +7 more
TL;DR: The results thus show that aurora B is responsible for mitotic arrest in the absence of aurora A, and that inactivation of Aurora B indeed bypasses the requirement for auroras A and leads to polyploidy.
Journal ArticleDOI
Synthesis, Structure−Activity Relationship, and Biological Studies of Indolocarbazoles as Potent Cyclin D1-CDK4 Inhibitors
Guoxin Zhu,Scott Eugene Conner,Xun Zhou,Chuan Shih,Tiechao Li,Bryan D. Anderson,Harold B. Brooks,Robert M. Campbell,Eileen L. Considine,Jack A. Dempsey,Margaret M. Faul,Cathy Ogg,Bharvin K. R. Patel,Richard M. Schultz,Charles D. Spencer,Beverly Teicher,Scott A. Watkins +16 more
TL;DR: 6-Substituted indolocarbazoles 4 were found to be potent and selective D1/CDK4 inhibitors that inhibited tumor cell growth, arrested tumor cells at the G1 phase, and inhibited pRb phosphorylation.