Swee Seong Wong

TL;DR: This work uses gene expression data to describe four molecular subtypes linked to distinct patterns of molecular alterations, disease progression and prognosis in gastric cancer, and describes key molecular alterations in each of the four subtypes using targeted sequencing and genome-wide copy number microarrays.

TL;DR: A web-based application called Cistrome, based on the Galaxy open source framework, that has 29 ChIP-chip- and Chip-seq-specific tools in three major categories, from preliminary peak calling and correlation analyses to downstream genome feature association, gene expression analyses, and motif discovery.

TL;DR: A subset of cancers highly sensitive to CDK4/6 inhibition is reported and characterized by various genomic aberrations known to elevate D-cyclin levels and a recurrent CCND1 3'UTR mutation associated with increased expression in endometrial cancer is described.

TL;DR: In this paper, the authors performed whole-genome sequencing of 49 GCs with diffuse (N=31) and intestinal (N = 18) histological subtypes and identified three mutational signatures, impacting TpT, CpG and TpCp[A/T] nucleotides.

TL;DR: Oncogenic BRAF deletions with a distinct activation mechanism dependent on the BRAF dimer formation in tumor cells are discovered and LY3009120 is active against these cells and represents a potential treatment option for patients with cancer, or other atypical BRAF mutations where BRAF functions as a dimer.