J
Jack D. Newman
Researcher at Amyris
Publications - 50
Citations - 7551
Jack D. Newman is an academic researcher from Amyris. The author has contributed to research in topics: Mevalonate pathway & Nucleic acid. The author has an hindex of 29, co-authored 50 publications receiving 6844 citations. Previous affiliations of Jack D. Newman include University of California, Berkeley & University of Wisconsin-Madison.
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Journal ArticleDOI
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
TL;DR: The strains developed in this study can serve as platform hosts for the production of any terpenoid compound for which a terpene synthase gene is available, and are the universal precursors to all isoprenoids.
Journal ArticleDOI
High-level semi-synthetic production of the potent antimalarial artemisinin
Christopher J. Paddon,Patrick J. Westfall,Douglas J. Pitera,Kirsten R. Benjamin,Karl Fisher,Derek McPhee,Michael D. Leavell,Anna Tai,A. Main,Diana Eng,Devin R Polichuk,Keat H. Teoh,Darwin W. Reed,T. Treynor,Jacob R. Lenihan,Hanxiao Jiang,M. Fleck,S. Bajad,G. Dang,D. Dengrove,Don Diola,G. Dorin,Kenneth W. Ellens,Scott Fickes,J. Galazzo,Sara P. Gaucher,T. Geistlinger,Ronald Henry,M. Hepp,Tizita Horning,T. Iqbal,L. Kizer,B. Lieu,D. Melis,Nathan A. Moss,Rika Regentin,S. Secrest,H. Tsuruta,R. Vazquez,Lars F. Westblade,Lan Xu,M. Yu,Yansheng Zhang,Lishan Zhao,Jefferson C. Lievense,Patrick S. Covello,Jay D. Keasling,K. K. Reiling,N. S. Renninger,Jack D. Newman +49 more
TL;DR: The strains and processes described here form the basis of a viable industrial process for the production of semi-synthetic artemisinin to stabilize the supply of art Artemisinin for derivatization into active pharmaceutical ingredients (for example, artesunate) for incorporation into ACTs.
Journal ArticleDOI
Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin
Patrick J. Westfall,Douglas J. Pitera,Jacob R. Lenihan,Diana Eng,Frank X. Woolard,Rika Regentin,Tizita Horning,Hiroko Tsuruta,David J. Melis,Andrew Owens,Scott Fickes,Don Diola,Kirsten R. Benjamin,Jay D. Keasling,Michael D. Leavell,Derek McPhee,Neil Stephen Renninger,Jack D. Newman,Chris J. Paddon +18 more
TL;DR: Progress is described toward the goal of developing a supply of semisynthetic artemisinin based on production of the art Artemisinin precursor amorpha-4,11-diene by fermentation from engineered Saccharomyces cerevisiae, and its chemical conversion to dihydroartemisinic acid, which can be subsequently converted to artemis inin.
Journal ArticleDOI
Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli.
TL;DR: The results demonstrate that balancing carbon flux through the heterologous pathway is a key determinant in optimizing isoprenoid biosynthesis in microbial hosts and eliminated the pathway bottleneck and increased mevalonate production.
Journal ArticleDOI
High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli.
Hiroko Tsuruta,Christopher J. Paddon,Diana Eng,Jacob R. Lenihan,Tizita Horning,Larry Cameron Anthony,Rika Regentin,Jay D. Keasling,Jay D. Keasling,Jay D. Keasling,Neil Stephen Renninger,Jack D. Newman +11 more
TL;DR: Production of >25 g/L amorpha-4,11-diene by fermentation followed by chemical conversion to artemisinin may allow for development of a process to provide an alternative source of art Artemisinin to be incorporated into ACTs.