S
Scott Fickes
Researcher at Amyris
Publications - 3
Citations - 2196
Scott Fickes is an academic researcher from Amyris. The author has contributed to research in topics: Artemisinin & Artemisia annua. The author has an hindex of 2, co-authored 3 publications receiving 1864 citations.
Papers
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Journal ArticleDOI
High-level semi-synthetic production of the potent antimalarial artemisinin
Christopher J. Paddon,Patrick J. Westfall,Douglas J. Pitera,Kirsten R. Benjamin,Karl Fisher,Derek McPhee,Michael D. Leavell,Anna Tai,A. Main,Diana Eng,Devin R Polichuk,Keat H. Teoh,Darwin W. Reed,T. Treynor,Jacob R. Lenihan,Hanxiao Jiang,M. Fleck,S. Bajad,G. Dang,D. Dengrove,Don Diola,G. Dorin,Kenneth W. Ellens,Scott Fickes,J. Galazzo,Sara P. Gaucher,T. Geistlinger,Ronald Henry,M. Hepp,Tizita Horning,T. Iqbal,L. Kizer,B. Lieu,D. Melis,Nathan A. Moss,Rika Regentin,S. Secrest,H. Tsuruta,R. Vazquez,Lars F. Westblade,Lan Xu,M. Yu,Yansheng Zhang,Lishan Zhao,Jefferson C. Lievense,Patrick S. Covello,Jay D. Keasling,K. K. Reiling,N. S. Renninger,Jack D. Newman +49 more
TL;DR: The strains and processes described here form the basis of a viable industrial process for the production of semi-synthetic artemisinin to stabilize the supply of art Artemisinin for derivatization into active pharmaceutical ingredients (for example, artesunate) for incorporation into ACTs.
Journal ArticleDOI
Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin
Patrick J. Westfall,Douglas J. Pitera,Jacob R. Lenihan,Diana Eng,Frank X. Woolard,Rika Regentin,Tizita Horning,Hiroko Tsuruta,David J. Melis,Andrew Owens,Scott Fickes,Don Diola,Kirsten R. Benjamin,Jay D. Keasling,Michael D. Leavell,Derek McPhee,Neil Stephen Renninger,Jack D. Newman,Chris J. Paddon +18 more
TL;DR: Progress is described toward the goal of developing a supply of semisynthetic artemisinin based on production of the art Artemisinin precursor amorpha-4,11-diene by fermentation from engineered Saccharomyces cerevisiae, and its chemical conversion to dihydroartemisinic acid, which can be subsequently converted to artemis inin.
Book ChapterDOI
Microbially Derived Semisynthetic Artemisinin
Christopher J. Paddon,Derek McPhee,Patrick J. Westfall,Kirsten R. Benjamin,Douglas J. Pitera,Rika Regentin,Karl Fisher,Scott Fickes,Michael D. Leavell,Jack D. Newman +9 more
TL;DR: Production of semisynthetic artemisinin may lead to the development of a second source of the drug for incorporation into ACTs, and may lead into a new generation of ACTs with potent antimalarial properties.