J
Jack Henkin
Researcher at Northwestern University
Publications - 149
Citations - 6846
Jack Henkin is an academic researcher from Northwestern University. The author has contributed to research in topics: Urokinase & Angiogenesis. The author has an hindex of 50, co-authored 145 publications receiving 6583 citations. Previous affiliations of Jack Henkin include University of Texas at Austin & University of Pennsylvania.
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Journal ArticleDOI
Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis: Implications for cellular surrogate marker analysis of antiangiogenesis
Yuval Shaked,Francesco Bertolini,Shan Man,Michael S. Rogers,Dave Cervi,Dave Cervi,Thomas J. Foutz,Kimberley Rawn,Daniel Voskas,Daniel Voskas,Daniel J. Dumont,Daniel J. Dumont,Yaacov Ben-David,Yaacov Ben-David,Jack Lawler,Jack Henkin,Jim Huber,Daniel J. Hicklin,Robert J. D'Amato,Robert S. Kerbel,Robert S. Kerbel +20 more
TL;DR: A striking correlation between highly genetically heterogeneous bFGF- or VEGF-induced angiogenesis and intrinsic CEC or CEP levels measured by flow cytometry is shown, among eight different inbred mouse strains.
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Structural requirements for the growth factor activity of the amino-terminal domain of urokinase.
Shafaat A. Rabbani,Andrew P. Mazar,Suzanne M. Bernier,Mahmudul Haq,Isabel Bolivar,Jack Henkin,David Goltzman +6 more
TL;DR: The results demonstrate that the GFD, implicated in binding to the uPA receptor, is also responsible for growth factor like activity in SaOS-2 cells and that the fucosylation at Thr18 within this domain may serve as a molecular trigger in eliciting this response.
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Paclitaxel at ultra low concentrations inhibits angiogenesis without affecting cellular microtubule assembly.
TL;DR: The data support a clinical application of continuous ultra- low dose paclitaxel to treat cancer and in vitro angiogenesis at low picomolar concentrations.
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Kringle 5 of Human Plasminogen Induces Apoptosis of Endothelial and Tumor Cells through Surface-Expressed Glucose-Regulated Protein 78
Don J. Davidson,Catherine J. Haskell,Sandy Majest,Abdullah Kherzai,David A. Egan,Karl A. Walter,Schneider Andrew J,Earl F. Gubbins,Larry Solomon,Zhebo Chen,Rick Lesniewski,Jack Henkin +11 more
TL;DR: Recombinant K5 is established as an inhibitor of a stress response pathway, which leads to both endothelial and tumor cell apoptosis, and glucose-regulated protein 78 plays a key role in the antiangiogenic and antitumor activity of K5.
Journal ArticleDOI
Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche
Michael P. Plebanek,Nicholas L. Angeloni,Elena Vinokour,Jia Li,Anna Henkin,Dalia Martinez-Marin,Stephanie Filleur,Reshma Bhowmick,Jack Henkin,Stephen D. Miller,Igal Ifergan,Yesung Lee,Iman Osman,C. Shad Thaxton,Olga V. Volpert +14 more
TL;DR: It is demonstrated that pre-metastatic tumors produce exosomes, which elicit a broad range of PMo-reliant innate immune responses via trigger(s) of immune surveillance, causing cancer cell clearance at the pre- metastatic niche.