J
Jacomine Krijnse-Locker
Researcher at Heidelberg University
Publications - 33
Citations - 5796
Jacomine Krijnse-Locker is an academic researcher from Heidelberg University. The author has contributed to research in topics: Viral replication & Virus. The author has an hindex of 27, co-authored 32 publications receiving 5388 citations. Previous affiliations of Jacomine Krijnse-Locker include University Hospital Heidelberg & Utrecht University.
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Journal ArticleDOI
Composition and three-dimensional architecture of the dengue virus replication and assembly sites.
Sonja Welsch,Sven Miller,Inés Romero-Brey,Andreas Merz,Christopher K. E. Bleck,Paul Walther,Stephen D. Fuller,Claude Antony,Jacomine Krijnse-Locker,Ralf Bartenschlager +9 more
TL;DR: Dengue virus (DENV) modifies ER membrane structure to promote replication and efficient encapsidation of the genome into progeny virus, which could explain the coordination of distinct steps of the flavivirus replication cycle.
Journal ArticleDOI
Modification of intracellular membrane structures for virus replication
TL;DR: How viruses modify intracellular membranes is described, similarities between the structures that are induced by viruses of different families are highlighted and how these structures could be formed are discussed.
Journal ArticleDOI
Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly.
Nicole Appel,Margarita Zayas,Sven Miller,Jacomine Krijnse-Locker,Torsten Schaller,Peter Friebe,Stephanie Kallis,Ulrike Engel,Ralf Bartenschlager +8 more
TL;DR: Novel insights are provided into the production of infectious HCV and NS5A is identified as a major determinant for HCV assembly, which suggests that viral isolates may differ in their level of virion production and thus in theirlevel of fitness and pathogenesis.
Journal ArticleDOI
Three-Dimensional Architecture and Biogenesis of Membrane Structures Associated with Hepatitis C Virus Replication
Inés Romero-Brey,Andreas Merz,Abhilash I. Chiramel,Ji-Young Lee,Petr Chlanda,Uta Haselman,Rachel Santarella-Mellwig,Anja Habermann,Simone Hoppe,Stephanie Kallis,Paul Walther,Claude Antony,Jacomine Krijnse-Locker,Ralf Bartenschlager +13 more
TL;DR: The morphology of the membranous rearrangements induced in HCV-infected cells resemble those of the unrelated picorna-, corona- and arteriviruses, but are clearly distinct from those from the closely related flavivirus.
Journal ArticleDOI
The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated manner.
TL;DR: It is demonstrated that NS4A associates with membranes via 4 internal hydrophobic regions, which are all able to mediate membrane targeting of a cytosolic reporter protein, and a model of how this protein induces membrane rearrangements and how this property may be regulated is provided.