Andreas Merz

TL;DR: Dengue virus (DENV) modifies ER membrane structure to promote replication and efficient encapsidation of the genome into progeny virus, which could explain the coordination of distinct steps of the flavivirus replication cycle.

TL;DR: The morphology of the membranous rearrangements induced in HCV-infected cells resemble those of the unrelated picorna-, corona- and arteriviruses, but are clearly distinct from those from the closely related flavivirus.

TL;DR: A rapid and efficient system for the production of large quantities of affinity-purified HCV allowing a comprehensive analysis of the infectious virion, including the determination of its lipid composition is described.

TL;DR: Cryo electron microscopy of vitreous sections must be considered the ‘gold standard’ among sectioning methods for electron microscope, because it avoids solvents and stains, but the use of optimally prepared freeze substitution also offers some advantages for ultrastructural analysis of bacteria.

TL;DR: Efficient production of E2-coated exosomes was shown to make hepatitis C virus less sensitive to antibody neutralization, which may have implications for the development of a hepatitis Cirus vaccine.