Jacqueline Inwald

TL;DR: The combined findings suggest that early BCG vaccines may even be superior to the later ones that are more widely used, and that further amplification of the DU2 region is ongoing, even within vaccine preparations used to immunize humans.

TL;DR: The phylogenetically informative spacers, in concert with the previously identified single nucleotide mutations and chromosomal deletions, can be used to identify a series of clades in the RD9 deleted lineage each with a separate host preference, and it is suggested that the M. tuberculosis complex may best be described as aseries of host-adapted ecotypes.

TL;DR: It is suggested that the clonal expansion of a genotype is caused either by the spread of a favorable mutation, together with all other genes present in the ancestral cell in which the mutation occurred, or by the invasion of a novel geographical region by a limited number of genotypes.

TL;DR: The disruption of a key step in glycolysis divides the M. tuberculosis complex into two groups with distinct carbon source utilization and explains the alteration in colony morphology noted during the derivation of BCG.

TL;DR: The molecular fingerprints of 1,349 isolates of Mycobacterium bovis received between 1979 and August 2000 at Agence Française de Sécurité Sanitaire des Aliments (Afssa) have been obtained by spoligotyping, revealing that the majority of the spolgotypes were closely related.