J
Jaehyung Cho
Researcher at University of Illinois at Chicago
Publications - 68
Citations - 3063
Jaehyung Cho is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Platelet & Protein disulfide-isomerase. The author has an hindex of 27, co-authored 59 publications receiving 2499 citations. Previous affiliations of Jaehyung Cho include Beth Israel Deaconess Medical Center & Washington University in St. Louis.
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Journal ArticleDOI
A critical role for extracellular protein disulfide isomerase during thrombus formation in mice
TL;DR: PDI is required in vivo in mice for both fibrin generation and platelet thrombus formation, and there is no stable accumulation of platelets in mice lacking the G protein-coupled platelets.
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Prevention of vascular inflammation by nanoparticle targeting of adherent neutrophils
TL;DR: Internalization of drug-loaded albumin nanoparticles into neutrophils inactivates the pro-inflammatory function of activated neutrophIL, thereby offering a promising approach for treating inflammatory diseases resulting from inappropriate neutrophil sequestration and activation.
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Scalable Generation of Universal Platelets from Human Induced Pluripotent Stem Cells
Qiang Feng,Namrata Shabrani,Jonathan N. Thon,Hongguang Huo,Austin T. Thiel,Kellie R. Machlus,Kellie R. Machlus,Kyungho Kim,Julie Brooks,Feng Li,Chenmei Luo,Erin A. Kimbrel,Jiwu Wang,Kwang-Soo Kim,Joseph E. Italiano,Jaehyung Cho,Shi-Jiang Lu,Robert Lanza +17 more
TL;DR: The scalable generation of HLA-ABC-negative platelets from a renewable cell source represents an important step toward generating universal platelets for transfusion as well as a potential strategy for the management of platelet refractoriness.
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Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice
Shi-Jiang Lu,Feng Li,Hong Yin,Qiang Feng,Erin A. Kimbrel,Eunsil Hahm,Jonathan N. Thon,Wei Wang,Joseph E. Italiano,Jaehyung Cho,Robert Lanza +10 more
TL;DR: It is reported that it is feasible to generate functional megakaryocytes and platelets from human embryonic stem cells (hESCs) on a large scale, and ultrastructural and morphological features of hESC-derived platelets were indistinguishable from those of normal blood platelets.
Journal ArticleDOI
Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice
Kyungho Kim,Eunsil Hahm,Jing Li,Lisa-Marie Holbrook,Parvathy Sasikumar,Ronald G. Stanley,Masuko Ushio-Fukai,Jonathan M. Gibbins,Jaehyung Cho +8 more
TL;DR: It is found that platelet PDI is important for thrombus formation on collagen-coated surfaces under shear and Intravital microscopy demonstrates that platelets accumulation but not initial adhesion and fibrin generation following laser-induced arteriolar injury.