J
Jagadeesan Arunakaran
Researcher at University of Madras
Publications - 128
Citations - 4509
Jagadeesan Arunakaran is an academic researcher from University of Madras. The author has contributed to research in topics: Prostate cancer & Oxidative stress. The author has an hindex of 37, co-authored 128 publications receiving 4030 citations.
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Induction of apoptosis in human breast cancer cells by nimbolide through extrinsic and intrinsic pathway
Perumal Elumalai,D.N. Gunadharini,Kalimuthu Senthilkumar,Sivanantham Banudevi,R. Arunkumar,Chellakkan Selvanesan Benson,G. Sharmila,Jagadeesan Arunakaran +7 more
TL;DR: It is suggested that nimbolide exhibit anticancer effect through its apoptosis-inducing property, and raises new hope for its use in anticancer therapy.
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Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3)
M.R. Vijayababu,A. Arunkumar,P. Kanagaraj,P. Venkataraman,Gunasekaran Krishnamoorthy,Jagadeesan Arunakaran +5 more
TL;DR: It is speculated that inhibition of metastasis-specific MMPs in cancer cells may be one of the targets for anticancer function of quercetin, and thus provides the molecular basis for the development of quERCetin as a novel chemopreventive agent for metastatic prostate cancer.
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Gold nanoparticle–conjugated quercetin inhibits epithelial–mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2-mediated pathway in breast cancer
S. Balakrishnan,Firdous Ahmad Bhat,P. Raja Singh,Shobha Mukherjee,Shobha Mukherjee,Perumal Elumalai,Suchandra Das,Suchandra Das,Chitta Ranjan Patra,Chitta Ranjan Patra,Jagadeesan Arunakaran +10 more
TL;DR: Gold nanoparticles are an efficient drug delivery vehicle for carrying chemotherapeutic agents to target cancer cells and quercetin is an anti‐oxidative flavonoid known with potent anti‐malignant cell activity.
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Studies on the protective role of vitamin C and E against polychlorinated biphenyl (Aroclor 1254)—induced oxidative damage in Leydig cells
TL;DR: It is suggested that vitamin C and E have ameliorative role against adverse effects of PCB on Leydig cell steroidogenesis and antioxidant system and Aroclor 1254 treatment significantly reduced the serum LH, TSH, PRL, T4, testosterone and estradiol.
Journal ArticleDOI
Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells (PC-3) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression.
M.R. Vijayababu,P. Kanagaraj,A. Arunkumar,R. Ilangovan,M. Michael Aruldhas,Jagadeesan Arunakaran +5 more
TL;DR: It was concluded that quercetin inhibits prostate cancer cell proliferation by altering the expression of cell cycle regulators and apoptotic proteins.