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Chellakkan Selvanesan Benson
Researcher at University of Madras
Publications - 8
Citations - 400
Chellakkan Selvanesan Benson is an academic researcher from University of Madras. The author has contributed to research in topics: Cell growth & Cell signaling. The author has an hindex of 7, co-authored 8 publications receiving 337 citations.
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Journal ArticleDOI
Induction of apoptosis in human breast cancer cells by nimbolide through extrinsic and intrinsic pathway
Perumal Elumalai,D.N. Gunadharini,Kalimuthu Senthilkumar,Sivanantham Banudevi,R. Arunkumar,Chellakkan Selvanesan Benson,G. Sharmila,Jagadeesan Arunakaran +7 more
TL;DR: It is suggested that nimbolide exhibit anticancer effect through its apoptosis-inducing property, and raises new hope for its use in anticancer therapy.
Journal ArticleDOI
Expression of matrix metalloproteinases in human breast cancer tissues.
Chellakkan Selvanesan Benson,Somasundaram Dinesh Babu,Selvi Radhakrishna,Nagarajan Selvamurugan,Bhaskaran Ravi Sankar +4 more
TL;DR: It is demonstrated that MMPs are differentially regulated in breast cancer tissues and they might play various roles in tumor invasion, metastasis and angiogenesis.
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Mechanism of apoptotic induction in human breast cancer cell, MCF-7, by an analog of curcumin in comparison with curcumin – An in vitro and in silico approach
Kumaravel Mohankumar,Sankar Pajaniradje,Subhashree Sridharan,Vivek Singh,Larance Ronsard,Akhil C. Banerjea,Chellakkan Selvanesan Benson,Mohane Selvaraj Coumar,Rukkumani Rajagopalan +8 more
TL;DR: Overall results showed that BDMC-A induced apoptosis more effectively compared to curcumin and the activity can be attributed to the presence of hydroxyl group in the ortho position in its structure.
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Effect of diallyl disulfide on insulin-like growth factor signaling molecules involved in cell survival and proliferation of human prostate cancer cells in vitro and in silico approach through docking analysis.
R. Arunkumar,G. Sharmila,Perumal Elumalai,Kalimuthu Senthilkumar,Sivanantham Banudevi,D.N. Gunadharini,Chellakkan Selvanesan Benson,P. Daisy,Jagadeesan Arunakaran +8 more
TL;DR: DADS decreases the survival rate of androgen independent prostate cancer cells by modulating the expression of IGF system, which leads to inhibition of phosphorylation of Akt, thereby inhibits cell cycle progression and survival.
Journal ArticleDOI
Ethanolic neem ( Azadirachta indica A. Juss) leaf extract induces apoptosis and inhibits the IGF signaling pathway in breast cancer cell lines
Perumal Elumalai,D.N. Gunadharini,Kalimuthu Senthilkumar,Sivanantham Banudevi,R. Arunkumar,Chellakkan Selvanesan Benson,G. Sharmila,Jagadeesan Arunakaran +7 more
TL;DR: It is suggested that ENLE induced apoptosis and decreased cell proliferation through the inhibition of the IGF signaling molecules in both MCF-7 and MDA MB-231 cells, which could be useful for breast cancer treatment.