J
Jagadeesan Nair
Researcher at International Agency for Research on Cancer
Publications - 36
Citations - 2290
Jagadeesan Nair is an academic researcher from International Agency for Research on Cancer. The author has contributed to research in topics: Lipid peroxidation & Betel. The author has an hindex of 22, co-authored 36 publications receiving 2234 citations. Previous affiliations of Jagadeesan Nair include German Cancer Research Center.
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Formation of 1,N6-ethenoadenine and 3,N4-ethenocytosine by lipid peroxidation products and nucleic acid bases.
TL;DR: The formation of etheno adducts may be markers of DNA damage associated with LPO, as demonstrated by reaction of LPO products with nucleic acid bases.
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Tobacco-specific and betel nut-specific N-nitroso compounds: occurrence in saliva and urine of betel quid chewers and formation in vitro by nitrosation of betel quid
TL;DR: The results indicate that N-nitroso compounds could easily be formed in vivo in the oral cavity during chewing or in the stomach after swallowing the quids, and the levels of N- Nitrosamines and alkaloids in betel quid extracts were determined before and after nitrosation at pH 7.1.
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1,N6-Ethenodeoxyadenosine and 3,N4-ethenodeoxycytidine in liver DNA from humans and untreated rodents detected by immunoaffinity/32P-postlabelling
TL;DR: In vitro studies indicated that these promutagenic DNA lesions could arise from endogenously formed lipid peroxidation products.
Journal Article
Cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells.
TL;DR: Comparisons of the areca nut-related N-nitroso compounds and their precursor alkaloids indicate that 3-(N-nitrosomethylamino)propionaldehyde is the most potent on a molar basis to decrease both survival and thiol content and to cause significant formation of DNA single strand breaks.
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Formation, detection, and role in carcinogenesis of ethenobases in DNA.
TL;DR: In this article, the formation, detection, and role in carcinogenesis of Ethenobases in Dna were discussed. But they did not consider the role of the Etheno-cell.