Showing papers in "Drug Metabolism Reviews in 1994"
TL;DR: The role of human Cytochromes P450 in the metabolic activation of Chemical Carcinogens and Toxins has been investigated in this paper, where it has been shown that P450 plays a crucial role.
Abstract: (1994). Role of Human Cytochromes P450 in the Metabolic Activation of Chemical Carcinogens and Toxins. Drug Metabolism Reviews: Vol. 26, No. 1-2, pp. 165-183.
501 citations
TL;DR: In this article, the formation, detection, and role in carcinogenesis of Ethenobases in Dna were discussed. But they did not consider the role of the Etheno-cell.
Abstract: (1994). Formation, Detection, and Role In Carcinogenesis of Ethenobases in Dna. Drug Metabolism Reviews: Vol. 26, No. 1-2, pp. 349-371.
159 citations
TL;DR: In this article, the authors studied the metabolism of Benzo's ultimate carcinogenic metabolite and found that it had a mutagenic profile similar to that of the pyrene.
Abstract: (1994). Studies on the Metabolism of Benzo[a]Pyrene and Dose-Dependent Differences in the Mutagenic Profile of Its Ultimate Carcinogenic Metabolite. Drug Metabolism Reviews: Vol. 26, No. 1-2, pp. 125-163.
147 citations
TL;DR: In this article, the effects of fluorine substitution on drug metabolism were investigated, and the effect of fluoroacetyl-fluorine substitutions on drugs was discussed.
Abstract: (1994). Effects of Fluorine Substitution on Drug Metabolism: Pharmacological and Toxicological Implications. Drug Metabolism Reviews: Vol. 26, No. 3, pp. 605-643.
122 citations
TL;DR: In this article, the polycyclic Hydrocarbon Activation: Bay Regions and Beyond is discussed. But the authors do not discuss the use of polycyclically-cyclic hydrocarbon activations in drug metabolism.
Abstract: (1994). Polycyclic Hydrocarbon Activation: Bay Regions and Beyond. Drug Metabolism Reviews: Vol. 26, No. 1-2, pp. 443-467.
106 citations
101 citations
84 citations
83 citations
TL;DR: In this article, the authors proposed a model for cancer prevention strategies based on metabolic activation and detoxification of tobacco-specific Nitrosamines. But they did not consider the effect of tobacco smoke on the model.
Abstract: (1994). Metabolic Activation and Detoxification of Tobacco-Specific Nitrosamines–A Model for Cancer Prevention Strategies. Drug Metabolism Reviews: Vol. 26, No. 1-2, pp. 373-390.
78 citations
76 citations
TL;DR: An overview of historical and current aspects of the role of metabolic activation in drug-induced cytotoxicity and concentrates on noncarcinogens is presented.
Abstract: It is now well recognized that metabolic activation of drugs to reactive metabolites is an important mechanism in many drug-induced toxicities. This paper presents an overview of historical and current aspects of the role of metabolic activation in drug-induced cytotoxicity and concentrates on noncarcinogens. As discussed in the other articles in this special issue, the role of metabolic activation in toxicology was discovered by Drs. James A. Miller and Elizabeth C. Miller at the McArdle Institute, University of Wisconsin, while working on mechanisms of carcinogenicity of aminoazo dyes. In 1947 these investigators [I] reported that the livers of rats fed the carcinogen N,N-dimethyl-4-aminoazobenzene contained aminoazo dye firmly bound to the protein, and that these adducts preceded the development of hepatic tumors. In subsequent work the Millers showed that formation of the protein adducts was a result of metabolism of the azo dye, and that the presence of the azo dye-protein adducts correlated with the carcinogenicity of the aminoazodye under a variety of conditions. These and subsequent *Contributed in honor of Elizabeth C. Miller, Ph.D., and James A. Miller, Ph.D.
TL;DR: In this article, the Cytochrome P450 in Human Fetal Liver: Significance and Fetal-Specific Expresson was discussed, and the importance of fetal specific expresson was highlighted.
Abstract: (1994). Cytochrome P450 in Human Fetal Liver: Significance and Fetal-Specific Expresson. Drug Metabolism Reviews: Vol. 26, No. 1-2, pp. 305-323.
TL;DR: In this article, the multistage nature of chemically induced hepatocarcinogenesis in the rat was investigated, and the results showed that it is possible to detect hepatic cancer in a rat.
Abstract: (1994). The Multistage Nature of Chemically Induced Hepatocarcinogenesis in the Rat. Drug Metabolism Reviews: Vol. 26, No. 1-2, pp. 209-220.
TL;DR: In this article, molecular modeling of Enzymes and Receptors Involved in Carcinogenesis: Qsars and Compacted-3D is presented, with a detailed discussion of the relationships between them.
Abstract: (1994). Molecular Modeling of Enzymes and Receptors Involved in Carcinogenesis: Qsars and Compacted-3D. Drug Metabolism Reviews: Vol. 26, No. 1-2, pp. 261-285.
TL;DR: In this article, genetic control of hepatocarcinogenesis in C3H mice is discussed. But the authors do not discuss the effects of the genetic control on the development of hepatocellular cancer.
Abstract: (1994). Genetic Control of Hepatocarcinogenesis In C3H Mice. Drug Metabolism Reviews: Vol. 26, No. 1-2, pp. 201-208.
TL;DR: The contribution of amine Oxidases to the metabolism of Xenobiotics is discussed in this paper, where the authors present an analysis of the relationship between amine oxidases and Xenobiotic metabolism.
Abstract: (1994). Contribution of Amine Oxidases to the Metabolism of Xenobiotics. Drug Metabolism Reviews: Vol. 26, No. 3, pp. 507-535.
TL;DR: The Mutational Spectrum of the P53 Tumor Suppressor Gene: Clues to Cancer Etiology and Molecular Pathogenesis as mentioned in this paper is a well-known source of information.
Abstract: (1994). Mutational Spectrum of the P53 Tumor Suppressor Gene: Clues to Cancer Etiology and Molecular Pathogenesis. Drug Metabolism Reviews: Vol. 26, No. 1-2, pp. 221-235.
TL;DR: In this article, the authors discuss the relevance of hydralazine to drug-induced Lupus and discuss its relevance in drug-induced liver cancer development, including liver transplantation.
Abstract: (1994). Metabolism of Hydralazine: Relevance to Drug-Induced Lupus. Drug Metabolism Reviews: Vol. 26, No. 3, pp. 485-505.
TL;DR: In this paper, the authors present a practical approach to Chemoprevention of Cancer using Drug Metabolism Reviews: Vol. 26, No. 1-2, pp. 253-260.
Abstract: (1994). Practical Approaches to Chemoprevention of Cancer. Drug Metabolism Reviews: Vol. 26, No. 1-2, pp. 253-260.
TL;DR: (1994).
Abstract: (1994). Toxic Effects and a Structure-Property Study of Organic Explosives, Propellants, and Related Compounds. Drug Metabolism Reviews: Vol. 26, No. 4, pp. 717-738.
TL;DR: A medium-term liver bioassay has been established in the laboratory using preneoplastic glutathione S-transferase placental form (GST-P) positive foci in the rat liver as endpoint marker lesions for rapid detection of carcinogenic and chemopreventive agents, and the positive rate was found to be extremely high.
Abstract: For rapid detection of carcinogenic agents, a medium-term liver bioassay has been established in our laboratory using preneoplastic glutathione S-transferase placental form (GST-P) positive foci in the rat liver as endpoint marker lesions A total of 237 compounds have so far been tested in this system and the results compared with reported Salmonella/microsome and long-term carcinogenicity test findings The positive rate was found to be extremely high, 97% (28 of 29 compounds) for genotoxic hepatocarcinogens; and satisfactory, 86% (23 of 27 chemicals) for nongenotoxic ones The positive rate for carcinogens targeting organs other than the liver, however, is relatively low (24%) Malathion and vinclozolin proved positive, although both have been reported to be noncarcinogenic in rats and mice Those chemicals which exerted positive results in this system might be hepatopromoting agents even if hepatocarcinogenicity has not been established Five of the six false-negative hepatocarcinogens could be categorized as peroxisome proliferators In addition, a number of inhibitory agents for GST-P-positive foci development have been detected and many are categorized as antioxidants The validity of this system as a tool for rapid detection of carcinogenic and chemopreventive agents is discussed
TL;DR: In this paper, a new metabolic reaction of potential toxicological significance was found in diarylimines, called N-oxidation of Diarylimines (N oxidation of diary-limines).
Abstract: (1994). Metabolic N-Oxidation of Diarylimines: A New Metabolic Reaction of Potential Toxicological Significance. Drug Metabolism Reviews: Vol. 26, No. 1-2, pp. 241-252.