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Alain Barbin
Researcher at International Agency for Research on Cancer
Publications - 47
Citations - 3222
Alain Barbin is an academic researcher from International Agency for Research on Cancer. The author has contributed to research in topics: Chloroacetaldehyde & Vinyl chloride. The author has an hindex of 31, co-authored 47 publications receiving 3190 citations. Previous affiliations of Alain Barbin include German Cancer Research Center & Institut de Chimie des Substances Naturelles.
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Validation and comparative studies on 180 chemicals with S. typhimurium strains and V79 Chinese hamster cells in the presence of various metabolizing systems.
Helmut Bartsch,Christian Malaveille,A.-M. Camus,Ghyslaine Martel-Planche,G. Brun,Agnès Hautefeuille,N. Sabadie,Alain Barbin,T. Kuroki,C. Drevon,C. Piccoli,Ruggero Montesano +11 more
TL;DR: The predictive value of the test, the quantitative relationship between mutagenicity versus electrophilicity versus carcinogenicity of some selected carcinogens, and some factors involved in the efficient detection of mutagens in vitro were analyzed.
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Formation of 1,N6-ethenoadenine and 3,N4-ethenocytosine by lipid peroxidation products and nucleic acid bases.
TL;DR: The formation of etheno adducts may be markers of DNA damage associated with LPO, as demonstrated by reaction of LPO products with nucleic acid bases.
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1,N6-Ethenodeoxyadenosine and 3,N4-ethenodeoxycytidine in liver DNA from humans and untreated rodents detected by immunoaffinity/32P-postlabelling
TL;DR: In vitro studies indicated that these promutagenic DNA lesions could arise from endogenously formed lipid peroxidation products.
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Etheno DNA-base adducts from endogenous reactive species
TL;DR: Epsilon-Adducts could hence be explored as biomarkers to ascertain the role of LPO mediated DNA damage in human cancers associated with oxidative stress imposed by certain lifestyle patterns, chronic infections and inflammations, and to verify the reduction of these ePSilon-adducts by cancer chemopreventive agents.
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Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues. Evidence for oxirane formation by P450-linked microsomal mono-oxygenases.
TL;DR: The hypothesis that an oxidation of the double bond in certain halo-olefins, which is dependent on microsomal mono-oxygenases is a common pathway in the formation of biologically reactive intermediates is supported.