J
Jagadeesh K. Venkatesan
Researcher at Saarland University
Publications - 56
Citations - 1201
Jagadeesh K. Venkatesan is an academic researcher from Saarland University. The author has contributed to research in topics: Cartilage & Chondrogenesis. The author has an hindex of 17, co-authored 48 publications receiving 958 citations.
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Transforming growth factor Beta-releasing scaffolds for cartilage tissue engineering.
TL;DR: The development of scaffolds that provide temporal and/or spatial control of TGF-β bioavailability has appeal as a mechanism to induce the chondrogenesis of stem cells in vitro and in vivo for articular cartilage repair.
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Current perspectives in stem cell research for knee cartilage repair
TL;DR: Various sources of progenitor cells are now available, originating from adult tissues but also from embryonic or reprogrammed tissues, most of which have already been evaluated for their chondrogenic potential in culture and for their reparative properties in vivo upon implantation in relevant animal models of cartilage lesions.
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SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells
Jagadeesh K. Venkatesan,Myriam Ekici,Henning Madry,Gertrud Schmitt,Dieter Kohn,Magali Cucchiarini +5 more
TL;DR: The potential benefits of rAAV-mediated SOX9 gene transfer to propagate hMSCs with an advantageous chondrocyte differentiation potential for future, indirect therapeutic approaches that aim at restoring articular cartilage defects in the human population are shown.
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Thermosensitive Hydrogel Based on PEO-PPO-PEO Poloxamers for a Controlled In Situ Release of Recombinant Adeno-Associated Viral Vectors for Effective Gene Therapy of Cartilage Defects
Henning Madry,Liang Gao,Ana Rey-Rico,Jagadeesh K. Venkatesan,Kathrin Müller-Brandt,Xiaoyu Cai,Lars Goebel,Gertrud Schmitt,Susanne Speicher-Mentges,David Zurakowski,Michael D. Menger,Matthias W. Laschke,Magali Cucchiarini +12 more
TL;DR: These comprehensive analyses of the entire osteochondral unit with multiple standardized evaluation methods indicate that rAAV‐FLAG‐hsox9/PEO–PPO–PEO hydrogel‐augmented microfracture significantly improves cartilage repair with a collagen fiber orientation more similar to the normal cartilage and protects the subchondral bone plate from early bone loss.
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Benefits of Recombinant Adeno-Associated Virus (rAAV)-Mediated Insulinlike Growth Factor I (IGF-I) Overexpression for the Long-Term Reconstruction of Human Osteoarthritic Cartilage by Modulation of the IGF-I Axis
Anja Weimer,Henning Madry,Jagadeesh K. Venkatesan,Gertrud Schmitt,Janina Frisch,Anna Wezel,Jochen Jung,Dieter Kohn,Ernest F. Terwilliger,Stephen B. Trippel,Magali Cucchiarini +10 more
TL;DR: The benefits of directly providing an IGF-I sequence to articular cartilage via rAAV for the future treatment of human osteoarthritis are shown, probably explaining the enhanced responsiveness of OA cartilage to IGF- I treatment.