Jaime H. Reina

TL;DR: The results reveal broad usage of the known Pol III transcription machinery and define a minimal Pol III transcriptome in dividing IMR90hTert fibroblasts, which does not contain any of the microRNA genes previously described as transcribed by Pol III, but reveals two other micro RNA genes, MIR886 and MIR1975, which are genuine PolIII transcription units.

TL;DR: The results describe molecular mechanisms by which mTORC1 controls human MAF1, a key repressor of RNA polymerase III transcription, and add a new branch to the signal transduction cascade immediately downstream of TORC1.

TL;DR: An in vivo functional analysis of an odorant binding protein in Drosophila challenges the established model of its role in pheromone signaling.

TL;DR: It is shown that human endogenous Maf1 can be co-immunoprecipitated with pol III and associates in vitro with two pol III subunits, the largest subunit RPC1 and the α-like subunit RPAC2, which suggest that Maf 1 is a major regulator of pol III transcription in human cells.

TL;DR: A model in which SNMP1 funnels hydrophobic pheromones from the extracellular fluid to integral membrane receptors is proposed, in which this ectodomain is essential, but intracellular and transmembrane domains dispensable, for cilia localization and phersomone-evoked responses.