抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Probability Distributions.- Linear Models for Regression.- Linear Models for Classification.- Neural Networks.- Kernel Methods.- Sparse Kernel Machines.- Graphical Models.- Mixture Models and EM.- Approximate Inference.- Sampling Methods.- Continuous Latent Variables.- Sequential Data.- Combining Models.

Pattern Recognition and Machine Learning

The modern science of networks has brought significant advances to our understanding of complex systems. One of the most relevant features of graphs representing real systems is community structure, or clustering, i. e. the organization of vertices in clusters, with many edges joining vertices of the same cluster and comparatively few edges joining vertices of different clusters. Such clusters, or communities, can be considered as fairly independent compartments of a graph, playing a similar role like, e. g., the tissues or the organs in the human body. Detecting communities is of great importance in sociology, biology and computer science, disciplines where systems are often represented as graphs. This problem is very hard and not yet satisfactorily solved, despite the huge effort of a large interdisciplinary community of scientists working on it over the past few years. We will attempt a thorough exposition of the topic, from the definition of the main elements of the problem, to the presentation of most methods developed, with a special focus on techniques designed by statistical physicists, from the discussion of crucial issues like the significance of clustering and how methods should be tested and compared against each other, to the description of applications to real networks.

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Community detection in graphs

We investigated the differential diffusion of all of the verified true and false news stories distributed on Twitter from 2006 to 2017. The data comprise ~126,000 stories tweeted by ~3 million people more than 4.5 million times. We classified news as true or false using information from six independent fact-checking organizations that exhibited 95 to 98% agreement on the classifications. Falsehood diffused significantly farther, faster, deeper, and more broadly than the truth in all categories of information, and the effects were more pronounced for false political news than for false news about terrorism, natural disasters, science, urban legends, or financial information. We found that false news was more novel than true news, which suggests that people were more likely to share novel information. Whereas false stories inspired fear, disgust, and surprise in replies, true stories inspired anticipation, sadness, joy, and trust. Contrary to conventional wisdom, robots accelerated the spread of true and false news at the same rate, implying that false news spreads more than the truth because humans, not robots, are more likely to spread it.

The spread of true and false news online

In this paper we investigate the attributes and relative influence of 1.6M Twitter users by tracking 74 million diffusion events that took place on the Twitter follower graph over a two month interval in 2009. Unsurprisingly, we find that the largest cascades tend to be generated by users who have been influential in the past and who have a large number of followers. We also find that URLs that were rated more interesting and/or elicited more positive feelings by workers on Mechanical Turk were more likely to spread. In spite of these intuitive results, however, we find that predictions of which particular user or URL will generate large cascades are relatively unreliable. We conclude, therefore, that word-of-mouth diffusion can only be harnessed reliably by targeting large numbers of potential influencers, thereby capturing average effects. Finally, we consider a family of hypothetical marketing strategies, defined by the relative cost of identifying versus compensating potential "influencers." We find that although under some circumstances, the most influential users are also the most cost-effective, under a wide range of plausible assumptions the most cost-effective performance can be realized using "ordinary influencers"---individuals who exert average or even less-than-average influence.

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Everyone's an influencer: quantifying influence on twitter

We study several longstanding questions in media communications research, in the context of the microblogging service Twitter, regarding the production, flow, and consumption of information. To do so, we exploit a recently introduced feature of Twitter known as "lists" to distinguish between elite users - by which we mean celebrities, bloggers, and representatives of media outlets and other formal organizations - and ordinary users. Based on this classification, we find a striking concentration of attention on Twitter, in that roughly 50% of URLs consumed are generated by just 20K elite users, where the media produces the most information, but celebrities are the most followed. We also find significant homophily within categories: celebrities listen to celebrities, while bloggers listen to bloggers etc; however, bloggers in general rebroadcast more information than the other categories. Next we re-examine the classical "two-step flow" theory of communications, finding considerable support for it on Twitter. Third, we find that URLs broadcast by different categories of users or containing different types of content exhibit systematically different lifespans. And finally, we examine the attention paid by the different user categories to different news topics.

/pdf/who-says-what-to-whom-on-twitter-204bj5cqww.pdf

Who says what to whom on twitter

Recent work has demonstrated that Web search volume can “predict the present,” meaning that it can be used to accurately track outcomes such as unemployment levels, auto and home sales, and disease prevalence in near real time. Here we show that what consumers are searching for online can also predict their collective future behavior days or even weeks in advance. Specifically we use search query volume to forecast the opening weekend box-office revenue for feature films, first-month sales of video games, and the rank of songs on the Billboard Hot 100 chart, finding in all cases that search counts are highly predictive of future outcomes. We also find that search counts generally boost the performance of baseline models fit on other publicly available data, where the boost varies from modest to dramatic, depending on the application in question. Finally, we reexamine previous work on tracking flu trends and show that, perhaps surprisingly, the utility of search data relative to a simple autoregressive model is modest. We conclude that in the absence of other data sources, or where small improvements in predictive performance are material, search queries provide a useful guide to the near future.

/pdf/predicting-consumer-behavior-with-web-search-1dvsg8gsjq.pdf

Predicting consumer behavior with Web search

Viral products and ideas are intuitively understood to grow through a person-to-person diffusion process analogous to the spread of an infectious disease; however, until recently it has been prohibitively difficult to directly observe purportedly viral events, and thus to rigorously quantify or characterize their structural properties. Here we propose a formal measure of what we label “structural virality” that interpolates between two conceptual extremes: content that gains its popularity through a single, large broadcast and that which grows through multiple generations with any one individual directly responsible for only a fraction of the total adoption. We use this notion of structural virality to analyze a unique data set of a billion diffusion events on Twitter, including the propagation of news stories, videos, images, and petitions. We find that across all domains and all sizes of events, online diffusion is characterized by surprising structural diversity; that is, popular events regularly grow ...

/pdf/the-structural-virality-of-online-diffusion-4k02vu52f4.pdf

The Structural Virality of Online Diffusion

With machine learning models being increasingly used to aid decision making even in high-stakes domains, there has been a growing interest in developing interpretable models. Although many supposedly interpretable models have been proposed, there have been relatively few experimental studies investigating whether these models achieve their intended effects, such as making people more closely follow a model's predictions when it is beneficial for them to do so or enabling them to detect when a model has made a mistake. We present a sequence of pre-registered experiments (N=3,800) in which we showed participants functionally identical models that varied only in two factors commonly thought to make machine learning models more or less interpretable: the number of features and the transparency of the model (i.e., whether the model internals are clear or black box). Predictably, participants who saw a clear model with few features could better simulate the model's predictions. However, we did not find that participants more closely followed its predictions. Furthermore, showing participants a clear model meant that they were less able to detect and correct for the model's sizable mistakes, seemingly due to information overload. These counterintuitive findings emphasize the importance of testing over intuition when developing interpretable models.

Jake M. Hofman

Papers

Everyone's an influencer: quantifying influence on twitter

Who says what to whom on twitter

Predicting consumer behavior with Web search

The Structural Virality of Online Diffusion

Manipulating and Measuring Model Interpretability