J
James A. Frank
Researcher at University of California, San Francisco
Publications - 60
Citations - 4035
James A. Frank is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Lung injury & Lung. The author has an hindex of 30, co-authored 59 publications receiving 3679 citations. Previous affiliations of James A. Frank include Cardiovascular Institute Hospital & University of California, Berkeley.
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Journal ArticleDOI
Doubt and belief in physicians' ability to prognosticate during critical illness: the perspective of surrogate decision makers
Lucas S. Zier,Jeffrey H. Burack,Guy Micco,Anne K. Chipman,James A. Frank,John M. Luce,Douglas B. White +6 more
TL;DR: Although many surrogate decision-makers harbor some doubt about the accuracy of physicians’ prognostications, they highly value discussions about prognosis and use the information for multiple purposes.
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Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade
TL;DR: IL-1 contributes to alveolar barrier dysfunction in VILI by promoting lung neutrophil recruitment and by increasing epithelial injury and permeability, and these data support further testing of IL-1Ra for the treatment of acute lung injury.
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Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs.
James A. Frank,Raphael Briot,Jae-Woo Lee,Akitoshi Ishizaka,Tokujiro Uchida,Michael A. Matthay +5 more
TL;DR: Data show that preserved AFC is a critical determinant of favorable lung fluid balance in the perfused human lung, raising the possibility that beta(2)-agonist therapy to increase edema fluid clearance may be of value for patients with acute lung injury and pulmonary edema.
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Integrin αvβ5 Regulates Lung Vascular Permeability and Pulmonary Endothelial Barrier Function
George Su,Maki Hodnett,Nanyan Wu,Amha Atakilit,Cynthia Kosinski,Mika Godzich,Xiao Zhu Huang,Jiyeun Kate Kim,James A. Frank,Michael A. Matthay,Dean Sheppard,Jean-Francois Pittet +11 more
TL;DR: Results identify integrin αvβ5 as a central regulator of increased pulmonary vascular permeability and a potentially attractive therapeutic target in ALI.
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Pulmonary epithelial barrier function: some new players and mechanisms.
TL;DR: This review of talks presented during a symposium in Experimental Biology geared toward novel and less recognized methods of epithelial barrier regulation discusses a few emerging paradigms of permeability changes through altered ion transport and paracellular regulation by which the epithelium gates its response to potentially detrimental luminal stimuli.