J
James A. Grifo
Researcher at New York University
Publications - 27
Citations - 1189
James A. Grifo is an academic researcher from New York University. The author has contributed to research in topics: Embryo transfer & Chlamydia trachomatis. The author has an hindex of 13, co-authored 27 publications receiving 1126 citations. Previous affiliations of James A. Grifo include NewYork–Presbyterian Hospital & Cornell University.
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Chromosome mosaicism in human embryos.
TL;DR: To assess the stage at which mosaicism occurred in preimplantation human embryos through use of fluorescence in situ hybridization (FISH) with multiple probes, full karyotypes of blastomeres from 2- to 8-cell human embryos are obtained.
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The use of first polar bodies for preimplantation diagnosis of aneuploidy
TL;DR: The rates of non-disjunction and unbalanced pre-division after > or = 24 h in culture were similar to the rates in fresh oocytes, and an increase of aneuploidy with maternal age was detected, which although slight, was significant.
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Diagnosing and preventing inherited disease: The use of first polar bodies for preimplantation diagnosis of aneuploidy
TL;DR: Because dyads seem to undergo rapid pre-division shortly after polar body retrieval, performance of FISH aneuploidy analysis of polar bodies is therefore only recommended when conducted within 6 h of their retrieval.
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Assessment of numeric abnormalities of X, Y, 18, and 16 chromosomes in preimplantation human embryos before transfer
Santiago Munné,K. Sultan,Heinz-Ulrich G. Weier,Heinz-Ulrich G. Weier,James A. Grifo,Jacques Cohen,Zev Rosenwaks +6 more
TL;DR: Fluorescence in situ hybridization is a more efficient method than cytogenetic analysis to study specific aneuploidies at preimplantation stages of development in human embryos and may increase the delivery rate per embryo by allowing only transfer of embryos normal for the tested chromosomes.
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Unsuspected Chlamydia trachomatis infection and in vitro fertilization outcome.
TL;DR: The relation between an unsuspected C. trachomatis infection and the ability of embryos to implant and develop after their transfer to the uterus is sought and may induce an inflammatory reaction in the uterus that impairs embryo implantation and/or facilitates immune rejection after uterine transfer of in vitro fertilized embryos.