James C. Leiter

TL;DR: The in vivo characteristics of custom-synthesized cerium oxide nanoparticles (CeNPs) in an animal model of immunological and free-radical mediated oxidative injury leading to neurodegenerative disease are reported to be well tolerated and taken up by the liver and spleen much less than previous nanoceria formulations.

TL;DR: Using a mouse hippocampal brain slice model of cerebral ischemia, it is shown that ceria nanoparticles reduce ischemic cell death by approximately 50% and suggests that scavenging of peroxynitrite may be an important mechanism by which cerium oxide nanoparticles mitigate isChemic brain injury.

TL;DR: This new implantable dopamine biosensor provides an alternative to fast scan cyclic voltammetry for in vivo monitoring of dopamine and demonstrates a detection limit of 1 nM dopamine, a linear range of 5 orders of magnitude between 10 nM and 220 microM, a sensitivity of 14.2 nA x microM(-1), and good selectivity against ascorbic acid, uric acid and serotonin.

TL;DR: Publication of a trial demonstrating large mortality reductions using small tidal volume was associated with significant reductions in tidal volume delivered to patients with ALI/ARDS, however, wide variation in practice persists, and the proportion of patients receiving tidal volumes within recommended limits remains modest.

TL;DR: By incorporating airway shape, airway size, and upper airway muscle activity into a unified hypothesis of the pathogenesis of OSA, it may be possible to reconcile discrepant anatomic and electromyographic findings in patients with OSA.