J
James D. Pomonis
Researcher at University of Minnesota
Publications - 24
Citations - 2594
James D. Pomonis is an academic researcher from University of Minnesota. The author has contributed to research in topics: Chronic pain & Neuropathic pain. The author has an hindex of 18, co-authored 24 publications receiving 2451 citations. Previous affiliations of James D. Pomonis include Veterans Health Administration & Purdue Pharma.
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Journal ArticleDOI
Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur
David B. Mach,Scott D. Rogers,Scott D. Rogers,Mary Ann C. Sabino,Mary Ann C. Sabino,Nancy M. Luger,Nancy M. Luger,Matthew J. Schwei,Matthew J. Schwei,James D. Pomonis,James D. Pomonis,Cathy P. Keyser,Cathy P. Keyser,Denis R. Clohisy,Douglas J. Adams,Patrick O'Leary,Patrick W. Mantyh,Patrick W. Mantyh +17 more
TL;DR: To define the peripheral fibers involved in transmitting and modulating skeletal pain, immunohistochemistry with antigen retrieval, confocal microscopy and three-dimensional image reconstruction of the bone was used to examine the sensory and sympathetic innervation of mineralized bone, bone marrow and periosteum of the normal mouse femur.
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N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropathic pain.
James D. Pomonis,James E. Harrison,Lilly Mark,David R. Bristol,Kenneth J. Valenzano,Katharine Walker +5 more
TL;DR: The effects of BCTC on acute, inflammatory, and neuropathic pain in rats suggest a role for VR1 in persistent and chronic pain arising from inflammation or nerve injury.
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Development and pharmacological characterization of a rat model of osteoarthritis pain
James D. Pomonis,Jamie Boulet,Susan L. Gottshall,Steve Phillips,Rani Sellers,Tracie E. Bunton,Katharine Walker +6 more
TL;DR: The iodoacetate model of OA is a relevant animal model to study pain associated with OA, and can be used to test potential therapeutic agents.
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Orphanin FQ, agonist of orphan opioid receptor ORL1, stimulates feeding in rats
TL;DR: It is reported that central injection of orphanin FQ induces feeding in satiated rats and that this effect can be blocked by peripheral administration of the opioid antagonist naloxone.
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Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs inflammatory pain.
Nancy M. Luger,Mary Ann C. Sabino,Matthew J. Schwei,David B. Mach,James D. Pomonis,Cathy P. Keyser,Michael Rathbun,Denis R. Clohisy,Prisca Honore,Tony L. Yaksh,Patrick W. Mantyh +10 more
TL;DR: It is shown that, as in humans, pain‐related behaviors are diminished by systemic morphine administration in a dose dependent fashion that is naloxone‐reversible, indicating that this model may be useful in defining drug therapies that are targeted for complex bone cancer pain syndromes.