L
Lilly Mark
Researcher at Pfizer
Publications - 8
Citations - 936
Lilly Mark is an academic researcher from Pfizer. The author has contributed to research in topics: Methicillin-resistant Staphylococcus aureus & Staphylococcus aureus. The author has an hindex of 4, co-authored 4 publications receiving 879 citations.
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Journal ArticleDOI
Loss of Retrograde Endocannabinoid Signaling and Reduced Adult Neurogenesis in Diacylglycerol Lipase Knock-out Mice
Ying Gao,Dmitry V. Vasilyev,Maria Beatriz De Castro Vasconcelos Goncalves,Fiona V. Howell,Carl Hobbs,Melina Reisenberg,Ru Shen,Mei-Yi Zhang,Brian W. Strassle,Peimin Lu,Lilly Mark,Michael J. Piesla,Kangwen Deng,Evguenia V. Kouranova,Robert H. Ring,Garth T. Whiteside,Brian Bates,Frank S. Walsh,Gareth Williams,Menelas N. Pangalos,Tarek A. Samad,Patrick Doherty +21 more
TL;DR: These findings provide the first evidence that DAGLα is the major biosynthetic enzyme for 2-AG in the nervous system and reveal an essential role for this enzyme in regulating retrograde synaptic plasticity and adult neurogenesis.
Journal ArticleDOI
N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropathic pain.
James D. Pomonis,James E. Harrison,Lilly Mark,David R. Bristol,Kenneth J. Valenzano,Katharine Walker +5 more
TL;DR: The effects of BCTC on acute, inflammatory, and neuropathic pain in rats suggest a role for VR1 in persistent and chronic pain arising from inflammation or nerve injury.
Journal ArticleDOI
Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system.
Pranab K. Chanda,Ying Gao,Lilly Mark,Joan Btesh,Brian W. Strassle,Peimin Lu,Michael J. Piesla,Mei-Yi Zhang,Brendan Bingham,Albert J. Uveges,Dianne Kowal,David S. Garbe,Evguenia Kouranova,Robert H. Ring,Brian Bates,Menelas N. Pangalos,Jeffrey D. Kennedy,Garth Whiteside,Tarek A. Samad +18 more
TL;DR: These findings provide the first genetic in vivo evidence that MAGL is the major regulator of 2-AG levels and signaling and reveal a pivotal role for 2- AG in modulating CB1 receptor sensitization and endocannabinoid tone.
Journal ArticleDOI
Pharmacology of 2-[4-(4-Chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: A Potent, Broad-Spectrum State-Dependent Sodium Channel Blocker for Treating Pain States
Victor I. Ilyin,James D. Pomonis,Garth Whiteside,James E. Harrison,Michelle S. Pearson,Lilly Mark,Paul I. Turchin,Susan L. Gottshall,Richard B. Carter,Phong Nguyen,Derk J. Hogenkamp,Shakira Olanrewaju,Elfrida R. Benjamin,Richard M. Woodward +13 more
TL;DR: The experiments suggest that high-potency, broad-spectrum, state-dependent Na+ channel blockers will have clinical utility for treating neuropathic, inflammatory, and postsurgical pain and Optimizing the biophysical parameters of broad-Spectrum voltage-gated Na+ channels may lead to improved pain therapeutics.
Journal ArticleDOI
Combination with a FtsZ inhibitor potentiates the in vivo efficacy of oxacillin against methicillin-resistant Staphylococcus aureus
Malvika Kaul,Edgar Ferrer-González,Lilly Mark,Ajit K. Parhi,Edmond J. LaVoie,Daniel S. Pilch +5 more
TL;DR: In this article , co-administering oxacillin with the FtsZ-targeting prodrug TXA709 (TXA707) rendered Oxacillin efficacious against MRSA.