J
James E. Galen
Researcher at University of Maryland, College Park
Publications - 3
Citations - 126
James E. Galen is an academic researcher from University of Maryland, College Park. The author has contributed to research in topics: Anthrax vaccines & Salmonella typhi. The author has an hindex of 3, co-authored 3 publications receiving 120 citations.
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Journal ArticleDOI
Adaptation of the endogenous Salmonella enterica serovar Typhi clyA-encoded hemolysin for antigen export enhances the immunogenicity of anthrax protective antigen domain 4 expressed by the attenuated live-vector vaccine strain CVD 908-htrA.
James E. Galen,Licheng Zhao,Magaly Chinchilla,Jin Yuan Wang,Marcela F. Pasetti,Jeffrey Green,Myron M. Levine +6 more
TL;DR: The utility of ClyA for enhancing the immunogenicity of an otherwise problematic antigen was demonstrated by engineering ClyA fused to the domain 4 (D4) moiety of Bacillus anthracis protective antigen (PA) and the induction of PA-specific gamma interferon and interleukin 5 responses was observed in splenocytes.
Journal ArticleDOI
Mucosal Immunization with Attenuated Salmonella enterica Serovar Typhi Expressing Protective Antigen of Anthrax Toxin (PA83) Primes Monkeys for Accelerated Serum Antibody Responses to Parenteral PA83 Vaccine
James E. Galen,Magaly Chincilla,Marcela F. Pasetti,Jin Yuan Wang,Licheng Zhao,Ivonne Arciniega-Martinez,David J. Silverman,Myron M. Levine +7 more
TL;DR: The success of this anthrax vaccine strategy based on heterologous mucosal priming followed by a parenteral subunit vaccine booster paves the way for clinical trials in nonhuman primates.
Book ChapterDOI
Chimeric Vaccines Against Japanese Encephalitis, Dengue, and West Nile
Rino Rappuoli,Andrew J. Pollard,E. Richard Moxon,Jay D. Wenger,Helen Campbell,Elizabeth L. Miller,David Salisbury,Orin S. Levine,David C. Klein,Jay C. Butler,David E. Briles,Susan K. Hollingshead,James C. Paton,Shousun C. Szu,John B. Robbins,Rachel Schneerson,Vince Pozsgay,Chiayung Chu,Myron M. Levine,James E. Galen,Carol O. Tacket,Eileen M. Barry,Marcela F. Pasetti,Sztein Marcelo,Mark S. Hanson,Robert Edelman,Jan Holmgren,Charlotta Bergquist,James B. Kaper,Robert J. Wilkinson,Douglas B. Young,John Treanor,James C. King,Kenneth M. Zangwill,Konstantin V. Pugachev,Thomas P. Monath,Farshad Guirakhoo +36 more