Anu Mahadevan

TL;DR: In macrophages, the endotoxin-induced synthesis of anandamide proceeds uniquely through the phospholipase C/phosphatase pathway, and conversion of synthetic NAPE to AEA by brain homogenates from wild-type and NAPE-PLD(-/-) mice can proceed through both the PLC/ph phosphatase and Abdh4 pathways.

TL;DR: The results strongly suggest that CB1 receptors may play a role in regulation of feeding behavior and that SR141716A may affect the actions of endogenous cannabinoids in regulating appetite.

TL;DR: The first potent and specific inhibitors of the biosynthesis of 2-AG that may be used as pharmacological tools to investigate the biological role of this endocannabinoid are reported.

TL;DR: The activities of the seven compounds in vivo did not correlate with their activities at either CB( 1) or VR(1) receptors, thus suggesting the existence of other brain sites of action mediating some of their neurobehavioral actions in mice.

TL;DR: Results suggest that the selective monoacylglycerol lipase (MAGL) inhibitor JZL184 reduces inflammatory nociception through the activation of both CB1 and CB2 receptors, with no evidence of tolerance following repeated administration of low doses.