J
James J. Salazar
Researcher at Galveston College
Publications - 7
Citations - 245
James J. Salazar is an academic researcher from Galveston College. The author has contributed to research in topics: DNA damage & DNA repair. The author has an hindex of 5, co-authored 7 publications receiving 238 citations. Previous affiliations of James J. Salazar include University of Texas Medical Branch.
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Journal ArticleDOI
Preferential mitochondrial DNA injury caused by glucose oxidase as a steady generator of hydrogen peroxide in human fibroblasts
TL;DR: Data show that GO-generated H202 causes acute damage to mtDNA and function, and demonstrate that this organelle is an important site for the cellular toxicity of ROS.
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Persistence, gestation stage-dependent formation and interrelationship of benzo[a]pyrene-induced DNA adducts in mothers, placentae and fetuses of Erythrocebus patas monkeys.
Lee Jane W. Lu,Lucy M. Anderson,Ann B. Jones,Thomas J. Moskal,James J. Salazar,James A. Hokanson,Jerry M. Rice +6 more
TL;DR: The results suggest that placental adduction accurately indicates fetal exposure and maximal sensitivity to transplacental DNA damage may be during mid-gestation, which is critical determinants in overall fetal risk to genetic damage.
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A model of sensitivity: 1,3-butadiene increases mutant frequencies and genomic damage in mice lacking a functional microsomal epoxide hydrolase gene.
Jeffrey K. Wickliffe,Marinel M. Ammenheuser,James J. Salazar,Sherif Z. Abdel-Rahman,Darlene A. Hastings-Smith,Edward M. Postlethwait,Edward M. Postlethwait,R. Stephen Lloyd,Jonathan B. Ward +8 more
TL;DR: The lack of mEH activity increases the genetic sensitivity of mice exposed to BD and BDO2, and a mechanistic understanding of the observed variation in human genetic sensitivity following exposure to BD is facilitated.
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Genetic Evidence for XPC-KRAS Interactions During Lung Cancer Development.
Xiaoli Zhang,Nonggao He,Dongsheng Gu,Jeffrey K. Wickliffe,James J. Salazar,Istavan Boldogh,Jingwu Xie +6 more
TL;DR: It is demonstrated that induced expression of oncogenic KRAS(G12V) led to increased levels of reactive oxygen species (ROS) as well as DNA damage, and both can be suppressed by anti-oxidants, suggesting that XPC may help repair DNA damage caused by KRAS-mediated production of ROS.
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Absence of formation of benzo[a]pyrene/DNA adducts in the cuttlefish (Sepia officinalis, Mollusca: Cephalopoda).
TL;DR: The dose of the carcinogen injected into the cuttlefish was 2—4 times higher than the dose resulting in the formation of a high level of B[a]P/DNA adducts in the vertebrates, which could explain the absence from the literature of reports of tumors in cephalopods.