J
James M. Flynn
Researcher at Buck Institute for Research on Aging
Publications - 19
Citations - 1411
James M. Flynn is an academic researcher from Buck Institute for Research on Aging. The author has contributed to research in topics: Mitochondrion & Oxidative stress. The author has an hindex of 15, co-authored 19 publications receiving 1152 citations. Previous affiliations of James M. Flynn include University of North Texas Health Science Center.
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Journal ArticleDOI
Late-life rapamycin treatment reverses age-related heart dysfunction
James M. Flynn,Monique N. O’Leary,Christopher A. Zambataro,Emmeline C. Academia,Michael P. Presley,Brittany J. Garrett,Artem Zykovich,Sean D. Mooney,Randy Strong,Clifford J. Rosen,Pankaj Kapahi,Michael D. Nelson,Brian K. Kennedy,Simon Melov +13 more
TL;DR: It is proposed that late‐life rapamycin therapy not only extends the lifespan of mammals, but also confers functional benefits to a number of tissues and mechanistically implicates an improvement in contractile function and antihypertrophic signaling in the aged heart with a reduction in age‐related inflammation.
Journal ArticleDOI
SOD2 in mitochondrial dysfunction and neurodegeneration.
James M. Flynn,Simon Melov +1 more
TL;DR: SOD2's potential involvement in the progression of neurodegenerative diseases such as stroke and Alzheimer and Parkinson diseases, as well as its potential role in "normal" age-related cognitive decline are reviewed.
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Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin
TL;DR: It is shown that the number of senescent cells, as well as impaired mitochondrial (complex II) activity increase in naturally aged mouse skin, and the idea that mitochondrial oxidative stress and cellular senescence contribute to aging skin phenotypes in vivo is supported.
Journal ArticleDOI
Analysis of individual cells identifies cell‐to‐cell variability following induction of cellular senescence
Christopher D. Wiley,James M. Flynn,Christapher S. Morrissey,Ronald Lebofsky,Joe Shuga,Xiao Dong,Marc A. Unger,Jan Vijg,Simon Melov,Judith Campisi,Judith Campisi +10 more
TL;DR: Together, these data offer new insights into how genes are regulated in senescence cells and suggest that single markers are inadequate to identify senescent cells in vivo.
Journal ArticleDOI
Genome-wide DNA methylation changes with age in disease-free human skeletal muscle.
Artem Zykovich,Alan Hubbard,James M. Flynn,Mark A. Tarnopolsky,Mario F. Fraga,Chad M. Kerksick,Dan Ogborn,Lauren G. MacNeil,Sean D. Mooney,Simon Melov +9 more
TL;DR: This work reports for the first time a genome‐wide study of DNA methylation dynamics in skeletal muscle of healthy male individuals during normal human aging and identifies 500 dmCpG sites that perform well in discriminating young from old samples.