Showing papers in "Experimental Neurology in 2007"

TL;DR: Results indicate adipose tissue contains a pool of regenerative stem cells which can be differentiated to a Schwann cell phenotype and may be of benefit for treatment of peripheral nerve injuries.

TL;DR: If anti- inflammatory interventions can be shown to rescue nigral DA neurons from degeneration and lower PD risk, then timely use of anti-inflammatory therapies should be investigated further in well-designed clinical trials for their ability to prevent or delay the progressive loss of nigralDA neurons in genetically susceptible populations.

TL;DR: The effect of brief stimulation on enhancing sensory and motoneuron regeneration holds promise for inducing improved peripheral nerve repair in the clinical setting.

TL;DR: Brain tissue from 18 cases who died after TBI and from 6 control cases was examined using immunohistochemistry to show rapid axonal accumulation of proteins implicated in neurodegenerative diseases including Alzheimer's disease and the synucleinopathies.

TL;DR: First direct in vivo evidence that caffeine and A(2A) receptor antagonists afford a protection against Abeta-induced amnesia, which prompts their interest for managing Alzheimer's disease is provided.

TL;DR: Diffusion tensor imaging is able to detect axonal injury, and the hypothesis that DTI may be more sensitive than conventional imaging methods for this purpose is supported.

TL;DR: Results taken together provide evidence indicating the strong association of neurotrophic factor production and the regenerative potential of implanted BMSCs.

TL;DR: Three tests that had never been reported in the mouse after ischemia are demonstrated to be useful for assessing both neuroprotective and regenerative therapies in stroke preclinical studies: adhesive removal, staircase and pole tests, which showed deficits 1 month after isChemia.

TL;DR: Inter intravenous infusion of paclitaxel induces a peripheral neuropathy characterized by injury of neuronal and non-neuronal cells in the peripheral nervous system, macrophage activation in both the DRG and peripheral nerve, and microglial activation within the spinal cord.

TL;DR: At the maximum tolerated dose bortezomib induced a significant reduction in SNCV, with a complete recovery at the end of the follow-up period, which is relevant to the neuropathy induced by bortzomib in the treatment of human malignancies.

TL;DR: The current data provide proof of the principle that excessive beta synchrony within the basal ganglia-cortical loop may contribute to the slowing of movements in Parkinson's disease.

TL;DR: It is demonstrated that further studies on minocycline in TBI are necessary in order to consider it as a novel therapy for brain-injured patients, as the early beneficial effect is likely not due to anti-apoptotic mechanisms.

TL;DR: Evidence relating to the protective effects of aspirin or other NSAIDs on DAergic neurons in animal models of Parkinson's disease will be discussed and the pharmacological mechanisms by which these molecules can exert their neuroprotective effects will be reviewed.

TL;DR: It is suggested that sepsis can induce persistent behavioral and neuroanatomical changes and warrant studies of the neurological long-term consequences of septicaemia in humans.

TL;DR: Long-lasting and selective impairment in adult hippocampal neurogenesis in a knock-in mutant mouse model of FAD is demonstrated and a novel mechanism by which amyloid and its attendant microglia-mediated neuroinflammation could contribute to the cognitive and behavioral abnormalities of AD is suggested.

TL;DR: The results provide the first comprehensive assessment of gastrointestinal pathophysiology in an animal model of PD and provide insight into the impact of dopaminergic dysfunction on gastrointestinal motility and a benchmark for assessment of other PD model systems.

TL;DR: The pilocarpine-treated mice seem to reflect several of the behavioral and cognitive disturbances that are associated with epilepsy in humans, which makes these animals an ideal model to study the neurobiological mechanisms underlying the association between epilepsy and psychopathology.

TL;DR: Data reported here suggest that clinically relevant doses of GLP-1 and Ex4 may offer some protection against the sensory peripheral neuropathy induced by pyridoxine, and suggest a potential role for these peptides in the treatment of neuropathies, including that associated with type II diabetes mellitus.

TL;DR: Measurements of HPA and SNS function as well as antigen-specific antibody synthesis against an exogenous non-self protein following high- or low-level SCI illustrate the immunosuppressive effects of the SNS after high- level SCI and indicate that immune deficits may be overcome using beta-blockers.

TL;DR: It is suggested that antidepressants have inhibitory effects on IFN-γ-activated microglia and these effects are, at least partially, mediated by the cAMP-dependent PKA pathway.

TL;DR: The data indicate that pharmacological blockade of TRPV1 receptors unmasks the anti-dyskinetic effects of FAAH inhibitors and that CB(1) and TRP V1 receptors play opposite roles in levodopa-induced dyskinesias.

TL;DR: The time course of cognitive recovery following lateral fluid percussion injury in rats and the proliferative response, maturational fate and integration of newly generated cells in the DG demonstrate the extensive anatomical integration of new born dentate granule neurons at the time when innate cognitive recovery is observed.

TL;DR: It is demonstrated that treatment with atorvastatin and simVastatin markedly reduced functional neurological deficits after traumatic brain injury in mice and improved cerebral hemodynamics following head injury, suggesting that the administration of statins may represent a viable therapeutic strategy in the acute treatment of closed head injury.

TL;DR: This study utilized chemically extracted acellular allogenic nerve segments implanted with autologous non-hematopoietic mesenchymal stem cells (MSCs) to repair a 40 mm defect in the rhesus monkey ulnar nerve.

TL;DR: Mitochondria size and mass are not the same for all neurons, and the SNC DA neurons have relatively low mitochondria mass, which may contribute to the selective vulnerability of these neurons in certain rodent models of PD.

TL;DR: The data show that in the pilocarpine model of temporal lobe epilepsy the latency period is short, and suggest that the model can be used for studies aiming at identifying the mechanisms of seizure clustering.

TL;DR: It is reported that pre-symptomatic treatment with the antidepressant paroxetine attenuates the disease process and improves cognitive performance in the 3xTgAD mouse model of AD, suggesting a preservation of cognitive function.

TL;DR: Findings indicate that inhibitory factors deposited at sites of chronic SCI do not create impenetrable boundaries and that inhibition can be balanced by local and diffusible signals to generate robust axonal growth even without resecting chronic scar tissue.

TL;DR: In vitro and in vivo electrical stimulation protocols employed in the hippocampal formation that are utilized in models of synaptic plasticity or neuronal hyperexcitability are compared.

TL;DR: The results demonstrate that this extract may be a potential candidate for the development of neuroprotective drug against the loss of RGCs in glaucoma, and the first in vivo report showing the therapeutic function of L. barbarum against neurodegeneration in the retina of rat OH model.