James M. McKim

TL;DR: Two in vivo fish preparation studies support the passive diffusion model for the uptake of organics at the gill-water interface and predict that high log P and melting point (low water solubility) may substantially reduce the rate of accumulation in fish.

TL;DR: The model accurately predicted the accumulation of PCE in blood and tissues, and its extraction from inspired water, demonstrating the potential utility of this model for use in aquatic toxicology and environmental risk assessment.

TL;DR: Seven blood characteristics — red blood cell count (RBC), hematocrit (Hc), hemoglobin (Hb), plasma chloride (Cl), plasma glutamic oxalacetic transaminase (PGOT, L-aspartate:2-oxoglutarate amino transferase), osmolarity (Os), and total protein (TP) — were measured in brook trout that had been exposed to three concentrations of Cu(II) for 6 and 21 days.

TL;DR: In this article, the development of fish acute toxicity syndromes (FATS), which are toxic-response sets based on various behavioral and physiological-biochemical measurements, and their projected use in the mode-of-action database are outlined.

TL;DR: A mathematical model for the exchange of neutral organic chemicals at fish gills was formulated based on limitations imposed by flows of water and blood to the gills, diffusion barriers defined by gill morphology, and chemical binding relationships.