J
James P. Luyendyk
Researcher at Michigan State University
Publications - 111
Citations - 5209
James P. Luyendyk is an academic researcher from Michigan State University. The author has contributed to research in topics: Liver injury & Tissue factor. The author has an hindex of 36, co-authored 101 publications receiving 4390 citations. Previous affiliations of James P. Luyendyk include University of Kansas & Scripps Research Institute.
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Journal ArticleDOI
Differential Roles of Unsaturated and Saturated Fatty Acids on Autophagy and Apoptosis in Hepatocytes
Shuang Mei,Hong-Min Ni,Sharon Manley,Abigail Bockus,Karen M. Kassel,James P. Luyendyk,Bryan L. Copple,Wen-Xing Ding +7 more
TL;DR: In line with the in vitro findings, it was found that high-fat diet-induced hepatic steatosis was associated with autophagy in the mouse liver and potential modulation of Autophagy may be a novel approach that has therapeutic benefits for obesity-induced steatotic and liver injury.
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The multifaceted role of fibrinogen in tissue injury and inflammation
TL;DR: There remains a critical need to define the precise temporal and spatial mechanisms by which fibrinogen-directed inflammatory events may dictate the severity of tissue injury and coordinate the remodeling and repair events essential to restore normal organ function.
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Genetic Analysis of the Role of the PI3K-Akt Pathway in Lipopolysaccharide-Induced Cytokine and Tissue Factor Gene Expression in Monocytes/Macrophages
James P. Luyendyk,Gernot Schabbauer,Michael Tencati,Todd Holscher,Rafal Pawlinski,Nigel Mackman +5 more
TL;DR: The results indicate that the PI3K-Akt pathway negatively regulates LPS signaling and gene expression in monocytes/macrophages and in mice.
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Nrf2 Promotes the Development of Fibrosis and Tumorigenesis in Mice with Defective Hepatic Autophagy
Hong-Min Ni,Benjamin L. Woolbright,Jessica A. Williams,Bryan L. Copple,Wei Cui,James P. Luyendyk,James P. Luyendyk,Hartmut Jaeschke,Wen-Xing Ding +8 more
TL;DR: Genetic evidence is provided that loss of autophagy in hepatocytes causes cell death resulting in liver inflammation, fibrosis and tumorigenesis, and it is demonstrated that persistent activation of Nrf2 is critical for liver inflammation and fibrosis, and eventual tumorigenisation that occur in mice with defects in hepatocyte Autophagy.
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Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1.
Ina Bergheim,Luping Guo,Molly Anne Davis,Jason C. Lambert,Juliane I. Beier,Ilinca Duveau,James P. Luyendyk,Robert A. Roth,Gavin E. Arteel +8 more
TL;DR: Findings suggest a novel mechanism of action for metformin and identify a new role of PAI-1 in hepatic injury caused by ethanol.