J
James P. O'Neil
Researcher at Lawrence Berkeley National Laboratory
Publications - 90
Citations - 7470
James P. O'Neil is an academic researcher from Lawrence Berkeley National Laboratory. The author has contributed to research in topics: Alzheimer's disease & Dopamine. The author has an hindex of 37, co-authored 90 publications receiving 5954 citations. Previous affiliations of James P. O'Neil include Helen Wills Neuroscience Institute & University of California, San Francisco.
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Journal ArticleDOI
PET Imaging of Tau Deposition in the Aging Human Brain
Michael Schöll,Michael Schöll,Samuel N. Lockhart,Daniel R. Schonhaut,James P. O'Neil,Mustafa Janabi,Rik Ossenkoppele,Rik Ossenkoppele,Rik Ossenkoppele,Suzanne L. Baker,Jacob W. Vogel,Jamie Faria,Henry Schwimmer,Gil D. Rabinovici,Gil D. Rabinovici,Gil D. Rabinovici,William J. Jagust,William J. Jagust +17 more
TL;DR: In this paper, the authors defined patterns of tau tracer retention in normal aging in relation to age, cognition, and β-amyloid deposition, and found that older age was associated with increased tracers retention in regions of the medial temporal lobe, which predicted worse episodic memory performance.
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Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease.
Rik Ossenkoppele,Rik Ossenkoppele,Rik Ossenkoppele,Daniel R. Schonhaut,Daniel R. Schonhaut,Michael Schöll,Michael Schöll,Samuel N. Lockhart,Nagehan Ayakta,Nagehan Ayakta,Suzanne L. Baker,James P. O'Neil,Mustafa Janabi,Andreas Lazaris,Averill Cantwell,Jacob W. Vogel,Miguel Santos,Zachary A. Miller,Brianne M. Bettcher,Brianne M. Bettcher,Keith A. Vossel,Joel H. Kramer,Maria Luisa Gorno-Tempini,Bruce L. Miller,William J. Jagust,William J. Jagust,Gil D. Rabinovici,Gil D. Rabinovici +27 more
TL;DR: Results are consistent with and expand upon findings from post-mortem, animal and cerebrospinal fluid studies, and suggest that the pathological aggregation of tau is closely linked to patterns of neurodegeneration and clinical manifestations of Alzheimer's disease.
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Aβ amyloid and glucose metabolism in three variants of primary progressive aphasia
Gil D. Rabinovici,William J. Jagust,Ansgar J. Furst,Ansgar J. Furst,Jennifer M. Ogar,Jennifer M. Ogar,Caroline A. Racine,Elizabeth C. Mormino,Elizabeth C. Mormino,James P. O'Neil,Rayhan A. Lal,Nina F. Dronkers,Nina F. Dronkers,Bruce L. Miller,Maria Luisa Gorno-Tempini +14 more
TL;DR: The relationships between language presentation, Aβ amyloidosis, and glucose metabolism in three PPA variants using [11C]‐Pittsburgh compound B and [18F]‐labeled fluorodeoxyglucose positron emission tomography are studied.
Journal ArticleDOI
Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease.
Alexandre Bejanin,Daniel R. Schonhaut,Renaud La Joie,Joel H. Kramer,Suzanne L. Baker,Natasha Sosa,Nagehan Ayakta,Averill Cantwell,Mustafa Janabi,Mariella Lauriola,James P. O'Neil,Maria Luisa Gorno-Tempini,Zachary A. Miller,Howard J. Rosen,Bruce L. Miller,William J. Jagust,William J. Jagust,Gil D. Rabinovici,Gil D. Rabinovici,Gil D. Rabinovici +19 more
TL;DR: Results show that tau pathology is related in a region-specific manner to cognitive impairment in Alzheimer's disease, and regional relationships are weakly related to amyloid burden, but are in part mediated by grey matter volumes.
Journal ArticleDOI
11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration
Gil D. Rabinovici,Ansgar J. Furst,James P. O'Neil,Caroline A. Racine,Elizabeth C. Mormino,Suzanne L. Baker,Sundari Chetty,Paras R. Patel,T. A. Pagliaro,William E. Klunk,Chet Mathis,Howard J. Rosen,Bruce L. Miller,William J. Jagust +13 more
TL;DR: PET imaging with 11C-labeled Pittsburgh Compound-B (11C-PIB) helps discriminate Alzheimer disease (AD) from frontotemporal lobar degeneration (FTLD).