Z
Zachary A. Miller
Researcher at University of California, San Francisco
Publications - 121
Citations - 5644
Zachary A. Miller is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Primary progressive aphasia & Frontotemporal dementia. The author has an hindex of 33, co-authored 99 publications receiving 3767 citations. Previous affiliations of Zachary A. Miller include Massachusetts Institute of Technology & University of Akron.
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Journal ArticleDOI
Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease.
Rik Ossenkoppele,Rik Ossenkoppele,Rik Ossenkoppele,Daniel R. Schonhaut,Daniel R. Schonhaut,Michael Schöll,Michael Schöll,Samuel N. Lockhart,Nagehan Ayakta,Nagehan Ayakta,Suzanne L. Baker,James P. O'Neil,Mustafa Janabi,Andreas Lazaris,Averill Cantwell,Jacob W. Vogel,Miguel Santos,Zachary A. Miller,Brianne M. Bettcher,Brianne M. Bettcher,Keith A. Vossel,Joel H. Kramer,Maria Luisa Gorno-Tempini,Bruce L. Miller,William J. Jagust,William J. Jagust,Gil D. Rabinovici,Gil D. Rabinovici +27 more
TL;DR: Results are consistent with and expand upon findings from post-mortem, animal and cerebrospinal fluid studies, and suggest that the pathological aggregation of tau is closely linked to patterns of neurodegeneration and clinical manifestations of Alzheimer's disease.
Journal ArticleDOI
Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease.
Alexandre Bejanin,Daniel R. Schonhaut,Renaud La Joie,Joel H. Kramer,Suzanne L. Baker,Natasha Sosa,Nagehan Ayakta,Averill Cantwell,Mustafa Janabi,Mariella Lauriola,James P. O'Neil,Maria Luisa Gorno-Tempini,Zachary A. Miller,Howard J. Rosen,Bruce L. Miller,William J. Jagust,William J. Jagust,Gil D. Rabinovici,Gil D. Rabinovici,Gil D. Rabinovici +19 more
TL;DR: Results show that tau pathology is related in a region-specific manner to cognitive impairment in Alzheimer's disease, and regional relationships are weakly related to amyloid burden, but are in part mediated by grey matter volumes.
Journal ArticleDOI
Prospective longitudinal atrophy in Alzheimer’s disease correlates with the intensity and topography of baseline tau-PET
Renaud La Joie,Adrienne Visani,Suzanne L. Baker,Jesse A. Brown,Viktoriya Bourakova,Jungho Cha,Kiran Chaudhary,Lauren Edwards,Leonardo Iaccarino,Mustafa Janabi,Orit H. Lesman-Segev,Zachary A. Miller,David C. Perry,James P. O'Neil,Julie Pham,Julio C. Rojas,Howard J. Rosen,William W. Seeley,Richard M. Tsai,Bruce L. Miller,William J. Jagust,William J. Jagust,Gil D. Rabinovici +22 more
TL;DR: Quantitative analyses showed that the global intensity of tau-PET, but not β-amyloid–PET, signal predicted the rate of subsequent atrophy, independent of baseline cortical thickness, which support disease models in which tau pathology is a major driver of local neurodegeneration.
Journal ArticleDOI
Typical and atypical pathology in primary progressive aphasia variants.
Edoardo G. Spinelli,Maria Luisa Mandelli,Zachary A. Miller,Miguel A. Santos-Santos,Stephen M. Wilson,Federica Agosta,Lea T. Grinberg,Eric J. Huang,John Q. Trojanowski,Marita Meyer,Maya L. Henry,Giancarlo Comi,Gil D. Rabinovici,Howard J. Rosen,Massimo Filippi,Bruce L. Miller,William W. Seeley,Maria Luisa Gorno-Tempini +17 more
TL;DR: In vivo signatures of pathological diagnosis in a large cohort of patients with primary progressive aphasia (PPA) variants defined by current diagnostic classification are characterized.
Journal ArticleDOI
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector
Chengzhong Wang,Ramsey Najm,Qin Xu,Dah-Eun Jeong,David Walker,Maureen E. Balestra,Seo Yeon Yoon,Heidi Yuan,Gang Li,Zachary A. Miller,Bruce L. Miller,Mary J. Malloy,Yadong Huang +12 more
TL;DR: Human iPSC-derived neurons are generated from individuals with or without Alzheimer's disease carrying different APOE alleles and reveal a toxic, neuron-intrinsic gain of function of the ApoE4 variant that is a strong genetic risk factor for AD.