J
James R. McLaughlan
Researcher at University of Leeds
Publications - 94
Citations - 1206
James R. McLaughlan is an academic researcher from University of Leeds. The author has contributed to research in topics: Microbubbles & Ultrasound. The author has an hindex of 17, co-authored 88 publications receiving 928 citations. Previous affiliations of James R. McLaughlan include St James's University Hospital & Boston University.
Papers
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A study of bubble activity generated in ex vivo tissue by high intensity focused ultrasound.
TL;DR: A suite of cavitation detection techniques that exploit passive and active acoustics, audible emissions and the electrical drive power fluctuations proved effective in both degassed water and tissue, but requires optimization for future clinical application.
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Expanding 3D geometry for enhanced on-chip microbubble production and single step formation of liposome modified microbubbles
Sally A. Peyman,Radwa H. Abou-Saleh,Radwa H. Abou-Saleh,James R. McLaughlan,Nicola Ingram,Benjamin R. G. Johnson,Kevin Critchley,Steven Freear,J. Anthony Evans,Alexander F. Markham,P. Louise Coletta,Stephen D. Evans +11 more
TL;DR: A new micro-spray flow regime is introduced that generates consistently high bubble concentrations that are more clinically relevant compared to traditional monodisperse bubble populations and is shown to be highly reproducible.
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Engineering Gold Nanotubes with Controlled Length and Near‐Infrared Absorption for Theranostic Applications
Sunjie Ye,Gemma Marston,James R. McLaughlan,Daniel O. Sigle,Nicola Ingram,Steven Freear,Jeremy J. Baumberg,Richard J. Bushby,Alexander F. Markham,Kevin Critchley,PL Coletta,Stephen D. Evans +11 more
TL;DR: The results demonstrate that these PSS‐coated Au NTs have the ideal attributes to develop their potential as effective and safe in vivo imaging nanoprobes, photothermal conversion agents, and drug delivery vehicles.
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On-chip preparation of nanoscale contrast agents towards high-resolution ultrasound imaging
Sally A. Peyman,James R. McLaughlan,Radwa H. Abou-Saleh,Radwa H. Abou-Saleh,Gemma Marston,Benjamin R. G. Johnson,Steven Freear,P. Louise Coletta,Alexander F. Markham,Stephen D. Evans +9 more
TL;DR: A new microfluidic method for the generation of sub-micron sized lipid stabilised particles containing perfluorocarbon gave excellent contrast enhancement when used for in vivo imaging, compared to microbubbles with an equivalent shell composition.
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Ultrasonic enhancement of photoacoustic emissions by nanoparticle-targeted cavitation
TL;DR: The strong acoustic emission and low-threshold fluence associated with ultrasound-assisted cavitation make the technique well suited for nanoparticle-targeted biological imaging and tissue therapy.