J
James R. Williamson
Researcher at Massachusetts Institute of Technology
Publications - 278
Citations - 20957
James R. Williamson is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: RNA & Ribosomal protein. The author has an hindex of 70, co-authored 264 publications receiving 18908 citations. Previous affiliations of James R. Williamson include Howard Hughes Medical Institute & Scripps Research Institute.
Papers
More filters
Journal ArticleDOI
Monovalent cation-induced structure of telomeric DNA: The G-quartet model
TL;DR: It is proposed that the G-quartet structure must be dealt with in vivo by the telomere replication machinery, hydrogen-bonded structures formed from four guanosine residues in a square-planar array.
Journal ArticleDOI
Inhibition of telomerase by G-quartet DNA structures.
TL;DR: Folding of telomeric DNA into G-quartet structures seems to influence the extent of telomere elongation in vitro and might therefore act as a negative regulator of lengthening in vivo.
Journal ArticleDOI
Addressing Preferred Specimen Orientation in Single-Particle Cryo-EM through Tilting
Yong Zi Tan,Philip R. Baldwin,Joseph H. Davis,James R. Williamson,Clinton S. Potter,Bridget Carragher,Dmitry Lyumkis +6 more
TL;DR: These methods were applied to determine the structures at near-atomic resolution of the influenza hemagglutinin trimer, which adopts a highly preferred specimen orientation, and of ribosomal biogenesis intermediates, which adopt moderately preferred orientations.
Journal ArticleDOI
α Helix-RNA Major Groove Recognition in an HIV-1 Rev Peptide-RRE RNA Complex
John L. Battiste,Hongyuan Mao,N. Sambasiva Rao,Ruoying Tan,D. R. Muhandiram,Lewis E. Kay,Alan D. Frankel,James R. Williamson +7 more
TL;DR: The solution structure of a human immunodeficiency virus type-1 (HIV-1) Rev peptide bound to stem-loop IIB of the Rev response element (RRE) RNA was solved by nuclear magnetic resonance spectroscopy.