Showing papers by "James Taylor published in 1982"
Journal Article•
TL;DR: Rat CRP closely resembled human CRP in its amino acid composition, in having five subunits per molecule and in its electron microscopic appearance as a pentameric annular disc, but differed from murine SAP which is a major acute phase reactant.
Abstract: C-reactive protein (RP) and serum amyloid P component (SAP) have been identified for the first time in rat serum and isolated by calcium-dependent affinity chromatography. Rat CRP closely resembled human CRP in its amino acid composition, in having five subunits per molecule and in its electron microscopic appearance as a pentameric annular disc. It differed, however, from all other mammalian CRP's characterised hitherto in being a glycoprotein bearing a single complex oligosaccharide on each polypeptide subunit. Furthermore one pair of tis subunits per molecule was linked by a interchain disulphide bridges whereas in other animals the subunits of both CRP and SAP are all non-covalently associated. The serum concentration of CRP in normal healthy laboratory rats and in specific pathogen-free rats was 300-600 micrograms/ml which is much greater than has been described in any other species and exceeds even maximal acute phase levels of CRP in man. Following injections of casein or croton oil, serum CRP levels rose to a maximum of about 900 micrograms/ml. Rat CRP bound to pneumococcal C-polysaccharide (CPS( but, in marked contrast to the behaviour of CRP from man, rabbit and marine teleost fish, it did not precipitate with CPS solutions, agglutinate CPS-coated sheep erythrocytes or initiate complement activation. Rat SAP, like SAP of other species, was a glycoprotein but unlike them it was composed only of a single pentameric disc not two such discs interacting face-to-face. The normal level of SAP in rat serum was 20-50 micrograms/ml, very similar to the levels seen in man, and it did not behave as an acute phase reactant in response to casein or croton-oil injections. In this respect it resembled human SAP but differed from murine SAP which is a major acute phase reactant.
166 citations
TL;DR: C-reactive protein was discovered by Tillett and Francis’ in the sera of patients with various infectious and inflammatory diseases as a material which precipitated pneumococcal C-polysaccharide (CPS) and was called the “acute phase protein” and this term was subsequently applied to the large number of other plasma proteins.
Abstract: C-reactive protein (CRP) was discovered by Tillett and Francis’ in the sera of patients with various infectious and inflammatory diseases as a material which precipitated pneumococcal C-polysaccharide (CPS). Subsequently Abernethy and Ave$ characterized CRP as a protein and identified the requirement for calcium ions in its interaction with CPS, while they and established that the appearance of CRP in the serum is a nonspecific response to infection, inflammation and tissue damage. Abernethy and Averf also introduced the term “acute phase sera” to designate samples obtained from patients in the acute phase of infectious diseases. CRP was called the “acute phase protein” and this term was subsequently applied to the large number of other plasma proteins, the concentrations of which are raised in acute phase sera. At an early stage Abernethy’ reported the presence of a precipitin comparable to CRP in acute phase monkey serum and, although he had been unable to find any in mouse or rabbit sera, Anderson and McCarty’later described the existence
162 citations
TL;DR: In this article, the cavity matching condition for optimum stable, picosecond pulse generation in a synchronously pumped c.w. mode locked dye laser has been achieved with an accuracy of 2 μm using a synchronized operated streak camera exhibiting a modest temporal resolution of 9 ps.
26 citations
TL;DR: Passive mode-locking of the coumarin 153 flashlamp pumped dye laser using the saturable absorber 3,3,dimethyl-9-ethyl thiacarbocyanine iodide is reported in this paper.
11 citations
TL;DR: The application of exact design by synthesis to elliptical switched-capacitor lowpass ladder filters of the lossless discrete integrator (LDI) type is described.
Abstract: The application of exact design by synthesis to elliptical switched-capacitor lowpass ladder filters of the lossless discrete integrator (LDI) type is described.
6 citations
TL;DR: Passive mode-locking of a flashlamp pumped coumarin 522 dye laser has been achieved, for the first time, using the saturable absorber 2-(p-dimethylaminostyryl)-benzothiazolylethyl iodide as discussed by the authors.
5 citations
TL;DR: In this article, the saturable absorber 2-(p-dimethylaminostyryl)-benzthiazolylelethyl iodide was used to produce pulses as short as 3 ps with pulse powers of up to 5 MW in a spectral range not previously covered.
Abstract: Flashlamp pumped coumarin 153 and rhodamine 110 dye lasers have been passively mode-locked for the first time using the saturable absorber 2-(p-dimethylaminostyryl)-benzthiazolylethyl iodide to produce pulses as short as 3 ps with pulse powers of up to 5 MW in a spectral range not previously covered.
5 citations
TL;DR: Using the saturable absorber 2-(p-Dimethylaminostyryl)-benzothiazolylethyl iodide, coumarin 6 has been passively mode-locked for the first time to give fully modulated trains of pulses of ∼4 ps duration and with peak powers of ∼3 MW tunable over the spectral range 526-547 nm as discussed by the authors.
Abstract: Using the saturable absorber 2-(p-Dimethylaminostyryl)-benzothiazolylethyl iodide, coumarin 6 has been passively mode-locked for the first time to give fully modulated trains of pulses of ∼4 ps duration and with peak powers of ∼3 MW tunable over the spectral range 526–547 nm.
3 citations
2 citations