J
Jamshed Iqbal
Researcher at COMSATS Institute of Information Technology
Publications - 231
Citations - 4278
Jamshed Iqbal is an academic researcher from COMSATS Institute of Information Technology. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 32, co-authored 151 publications receiving 3342 citations. Previous affiliations of Jamshed Iqbal include University of Düsseldorf & Forman Christian College.
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Quinazolines and quinazolinones as ubiquitous structural fragments in medicinal chemistry: An update on the development of synthetic methods and pharmacological diversification
TL;DR: The main focus of the present review is to provide an ample but condensed overview on various synthetic approaches providing access to quinazoline andQuinazolinone compounds with multifaceted biological activities.
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Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors.
TL;DR: One of the compounds, (NH(4))(18)[NaSb(9)W(21)O(86)], was selective for NTPDases2 and 3 versus NTPDase1, and might contribute to the described biological effects of polyoxometalates, including their anti-cancer activity.
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Synthesis, biological assay in vitro and molecular docking studies of new Schiff base derivatives as potential urease inhibitors.
TL;DR: A series of new and novel Schiff base derivatives were synthesized and investigated as potential new inhibitors of Jack bean urease and it was observed that both share the same binding mode.
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Therapeutic potentials of ecto-nucleoside triphosphate diphosphohydrolase, ecto-nucleotide pyrophosphatase/phosphodiesterase, ecto-5'-nucleotidase, and alkaline phosphatase inhibitors.
Mariya al-Rashida,Jamshed Iqbal +1 more
TL;DR: Most recent and significant advances in field of NTPDase, NPP, AP, and e5NT inhibitors is being discussed in detail in anticipation of providing prolific leads and relevant background for research groups interested in synthesis of selective ecto‐nucleotidase inhibitors.
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Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold.
Younis Baqi,Sang-Yong Lee,Jamshed Iqbal,Peter Ripphausen,Anne Lehr,Anja B. Scheiff,Herbert Zimmermann,Jürgen Bajorath,Christa E. Müller +8 more
TL;DR: Investigations of ecto-nucleoside triphosphate diphosphate Diphosphohydrolases and the P2Y receptor subtypes showed that compound 45 exhibited the highest degree of selectivity (>150-fold), with 52 being the most potent eN inhibitor described to date.