Jan A. Mennigen

TL;DR: The neuroendocrine control of luteinizing hormone is described and isotocin (fish homologue of oxytocin) and activins are regulated by multiple neurotransmitters, which is discussed in light of their roles in reproduction in other species.

TL;DR: The evolutionary conservation of the 5-HT transporter is described and the disruptive effects of fluoxetine on several physiological endpoints, including involvement of neuroendocrine mechanisms are reviewed, which may be helpful in designing targeted approaches for future risk assessments of pharmaceuticals disrupting the neuro endocrine system in general.

TL;DR: The results reveal targets of serotonergic modulation in the neuroendocrine brain and indicate that fluoxetine has the potential to affect sex hormones and modulate genes involved in reproductive function and behavior in the brain of female goldfish.

TL;DR: It is demonstrated that FLX disrupts reproductive physiology of male fish at environmentally relevant concentrations, and potential mechanisms are discussed.

TL;DR: Overall, this study demonstrated anorectic properties of FLX at a dose of 54 μg/LFLX and moderate but significant effects on glucose metabolism in goldfish exposed to 540 ng/L FLX.